Neuroscience 2001 Abstract
| Presentation Number: | 335.12 |
|---|---|
| Abstract Title: | The pathophysiology of the anterior cingulate region in schizophrenia:magnetic resonance imaging and spectroscopy studies. |
| Authors: |
Yamasue, H.*1
; Kuroki, N.1
; fukui, M.2
; fukuda, R.1
; yamada, H.2
; kasai, K.3
; katou, T.1,4
; tsujii, K.1
; iwanami, A.1
; abe, O.2
; abe, O.2
; katou, N.1
1Dept Neuropsychiat, Grad Sch Med Univ Tokyo, Tokyo, Japan 2Dept Ragiology, Grad Sch Med Univ Tokyo, Tokyo, Japan 3Dept Psychiatry, Harvard Med Sch, Brockton, MA 4Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Wako, Japan |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Psychiatric Disorders -- Schizophrenia |
| Session: |
335. Psychiatric disorders: schizophrenia--neuropsychological, imaging and genetic studies II Poster |
| Presentation Time: | Monday, November 12, 2001 11:00 AM-12:00 PM |
| Location: | Exhibit Hall AAA-38 |
| Keywords: | MRI, MRS, MORPHOMETRY, CINGULATE |
Previous studies have indicated that the anterior cingulate region may play an important role in the pathophysiology of schizophrenia. We used 3D magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (MRS) to measure gray matter volumes, the neuronal marker N-acetylaspartate (NAA), choline and creatine in the anterior cingulate region of 8 chronic schizophrenic subjects and 8 matched normal control subjects, all right-handed. MRI volumetric measurements and MRS date were obtained on a GE 1.5 Tesla Signa system. Gray matter volume was significantly reduced in the left anterior cingulate region in schizophrenic patients compared with normal control subjects. Relative to normal control subjects, schizophrenic patients demonstrated slightly lower NAA in left anterior cingulate regions. There was no significant correlation between reduced gray matter volume and lower NAA in anterior cingulate region of both schizophrenic patients and normal control subjects. This finding indicates either neuronal dysfunction or neuronal loss in the anterior cingulate region of schizophrenia.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
Copyright © 2001-2025 Society for Neuroscience; all rights reserved. Permission to republish any abstract or part of any abstract in any form must be obtained in writing by SfN office prior to publication.
