Neuroscience 2005 Abstract
| Presentation Number: | 283.10 |
|---|---|
| Abstract Title: | Changes in cortical activity during functional electrical therapy assessed by functional magnetic resonance imaging. |
| Authors: |
Iftime, S. D.*1
; Vingborg, R.2
; Sinkjær, T.1
; Roepstorff, A.2
; Grey, M. J.1
1Center for Sensory-Motor Interaction, Aalborg Univ., Aalborg, Denmark 2Denmark, Fredric Bajersvej 7D3, DK9220, |
| Primary Theme and Topics |
Sensory and Motor Systems - Multisensory |
| Secondary Theme and Topics | Disorders of the Nervous System<br />- Neurodegenerative and Movement Disorders<br />-- Other |
| Session: |
283. Multisensory: Cross-Modal Processing I Poster |
| Presentation Time: | Sunday, November 13, 2005 2:00 PM-3:00 PM |
| Location: | Washington Convention Center - Hall A-C, Board # X17 |
| Keywords: | BRAIN IMAGING, ELECTRICAL STIMULATION, STROKE, REHABILITATION |
This study assessed, via fMRI, changes in cortical activity during a training session with Functional Electrical Therapy (FET) - a rehabilitative therapy that combines voluntary activation with patterned Functional Electrical Stimulation of muscles (FES).
Five able bodied subjects participated in this study. Each subject was instrumented with surface stimulation electrodes positioned over motor points of the finger flexor/extensors muscles on the right arm. A button press with the left index finger initiated patterned electrical stimuli (50 Hz, 200 ìs pulse duration, 8-15 mA pulse amplitude) to produce right hand opening and closing. Right index finger flexion/extension was recorded with a goniometer. Subjects were scanned in a 3T GE scanner using standard fMRI methods in a randomized block design paradigm with 5 different conditions: rest, voluntary activation (VA), imagined movement, FES, and FET. Each task lasted 30 s and repeated 5 times.
Data were realigned, smoothed and normalized using standard procedures (SPM2). Tasks were modeled in a fixed effect analysis; subtraction SPM images were thresholded at 0.05 and family-wise error corrected for multiple comparisons. There was no significant difference in finger flexion movements between the VA, FES, and FET tasks. When compared with rest, FES, FET and VA all showed activity in a mainly left lateralized network including primary sensory-motor regions. When compared with FES, FET showed activity in the right posterior cerebellum only. When compared, with VA, both FET and FES generated bilateral inferior parietal activity but no significant activity in the primary sensory-motor regions. This suggests that both FES and FET evoke activity in regions that have been associated with proprioception.
Five able bodied subjects participated in this study. Each subject was instrumented with surface stimulation electrodes positioned over motor points of the finger flexor/extensors muscles on the right arm. A button press with the left index finger initiated patterned electrical stimuli (50 Hz, 200 ìs pulse duration, 8-15 mA pulse amplitude) to produce right hand opening and closing. Right index finger flexion/extension was recorded with a goniometer. Subjects were scanned in a 3T GE scanner using standard fMRI methods in a randomized block design paradigm with 5 different conditions: rest, voluntary activation (VA), imagined movement, FES, and FET. Each task lasted 30 s and repeated 5 times.
Data were realigned, smoothed and normalized using standard procedures (SPM2). Tasks were modeled in a fixed effect analysis; subtraction SPM images were thresholded at 0.05 and family-wise error corrected for multiple comparisons. There was no significant difference in finger flexion movements between the VA, FES, and FET tasks. When compared with rest, FES, FET and VA all showed activity in a mainly left lateralized network including primary sensory-motor regions. When compared with FES, FET showed activity in the right posterior cerebellum only. When compared, with VA, both FET and FES generated bilateral inferior parietal activity but no significant activity in the primary sensory-motor regions. This suggests that both FES and FET evoke activity in regions that have been associated with proprioception.
Supported by Danish National Research Foundation & Danish Research Council for Humanities
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
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