Neuroscience 2003 Abstract
| Presentation Number: | 241.11 |
|---|---|
| Abstract Title: | Functional magnetic resonance imaging (fMRI) during forced expiratory effort in congenital central hypoventilation syndrome (CCHS). |
| Authors: |
Macey, K. E.*1
; Macey, P. M.1
; Alger, J. R.2,3
; Woo, M. A.4
; Harper, R. K.1
; Harper, R. M.1,3
1Dept. NeuroBiol., UCLA, Los Angeles, CA 2Dept. Radiology, UCLA, Los Angeles, CA 3Brain Res. Inst., UCLA, Los Angeles, CA 4Sch. of Nursing, UCLA, Los Angeles, CA |
| Primary Theme and Topics |
Autonomic, Neuroendocrine and Other Homeostatic Systems - Autonomic -- Respiratory regulation |
| Secondary Theme and Topics | Autonomic, Neuroendocrine and Other Homeostatic Systems<br />- Autonomic<br />-- Cardiovascular regulation |
| Session: |
241. Respiratory Neurobiology Slide |
| Presentation Time: | Sunday, November 9, 2003 3:30 PM-3:30 PM |
| Location: | Morial Convention Center - Room 398 |
| Keywords: | RESPIRATION, BLOOD PRESSURE, SLEEP, CARDIOVASCULAR |
CCHS patients show impaired ventilatory responses to CO2 and hypoxia, a reduced drive to breathe during sleep, and aberrant cardiovascular responses to blood pressure elevation, suggesting deficient central neural regulatory processes. We examined fMRI signal changes in the brain for thirteen CCHS patients (age: mean 11, and range 8-15 years; no Hirschsprung’s, pulmonary, cardiac or neuromuscular disease) and fourteen age- and gender-matched control subjects to forced expiratory effort, a challenge that induces blood pressure elevation. Two fMRI series were collected while patients lay supine in the scanner. The first series was a 150 s baseline, where subjects breathed normally through a mouthpiece; the second consisted of 30 s baseline, followed by 120 s forced expiratory effort, where subjects breathed against a closed glottis. Images were adjusted for slice timing differences, motion corrected, spatially normalized, segmented into gray matter, smoothed and intensity normalized. Random-effects analysis and a priori volume-of-interest analysis showed normal signal patterns in the temporal lobe and cerebellar dentate nucleus. Abnormal signal patterns adjacent to normal signals emerged in the insula, left amygdala, left hippocampus, left putamen, cerebellar quadrangular lobule, vermis, fastigial nucleus, midbrain and pons. Abnormal patterns also developed in the head of caudate nucleus and within the ventral medulla. The findings suggest that motor and autonomic coordination areas of the cerebellum, as well as motor areas within the pons and basal ganglia, contribute to deficient responses in CCHS. Aberrant limbic functions may contribute to impaired initiation of breathing efforts and abnormal cardiovascular control.
Supported by NICHD-HD-22695
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2003 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2003. Online.
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