Neuroscience 2004 Abstract
| Presentation Number: | 226.4 |
|---|---|
| Abstract Title: | Diagnostic value of structural magnetic resonance imaging in mild cognitive impairment and Alzheimer's disease: A longitudinal study. |
| Authors: |
Kabani, N.*1
; Dorr, A.2
; Chertkow, H.3
; Sled, J. G.
1Sunnybrook Hlth. Sci. Centre, Toronto, Canada 2PQ, 3080 Yonge St., Suite 6020 A, M4N3N1, 3Canada, 3080 Yonge St., Suite 6020 A, M4N3N1, |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Neurodegenerative Disorders -- Other |
| Secondary Theme and Topics | Cognition and Behavior<br />- Human Cognition, Behavior, and Anatomy<br />-- Anatomy |
| Session: |
226. Neurodegeneration Mechanisms I Poster |
| Presentation Time: | Sunday, October 24, 2004 11:00 AM-12:00 PM |
| Location: | San Diego Convention Center - Hall A-H, Board # XX28 |
| Keywords: | Magnetic resonance imaging, magnetization transfer ratio, mild cognitive impairment, Alzheimer's disease |
We present here novel findings using magnetization transfer (MT) contrast imaging for effective early diagnosis of mild cognitive impairment (MCI) as well as prediction of MCI progression to Alzheimer’s disease (AD). The goal of this study was to compare the sensitivity and specificity of two structural MRI measures of the hippocampus, volumetric analysis (H-V) and MT-ratio (H-MTR). For this purpose MRI acquired two years previously was evaluated for its predictive value of disease progression on follow-up.
High resolution T1-weighted and MT-contrast images from time-1 scan of 27 MCI, 10 AD and 14 normal elderly (NE) subjects were manually segmented for hippocampus to determine the H-V and H-MTR. When clinical status of their condition was evaluated two years later, 9 of the MCI subjects had progressed (MCI-P) to AD while 18 remained stable (MCI-NP).
Discriminant functional analysis showed that the sensitivity (81%) and specificity (53%) was same for both H-MTR and H-V in separating the NE from the MCI at time-1. However by including the MMSE score, the sensitivity and specificity of the H-MTR increased to 100% (89% for H-V) and 58% (57% for H-V) respectively.
While seperating MCI-P and MCI-NP, the H-MTR had a higher specificity (94%) and sensitivity (70%) compared to H-V, 88% and 60% respectively. The positive predictive value (proportion of MCI with a positive test who would develop AD) was 88% for H-MTR and 75% for H-V. The negative predictive value (proportion of MCI with a negative test who would remain stable) was 83% for H-MTR and 78% for H-V.
Among the MR imaging methods, when compared to the traditional volumetric analysis, MTR is a more sensitive and specific measure to separate NE from the MCI and also for distinguishing between the MCI progressors and non-progressors.
Support: Alz-Can, CIHR.
High resolution T1-weighted and MT-contrast images from time-1 scan of 27 MCI, 10 AD and 14 normal elderly (NE) subjects were manually segmented for hippocampus to determine the H-V and H-MTR. When clinical status of their condition was evaluated two years later, 9 of the MCI subjects had progressed (MCI-P) to AD while 18 remained stable (MCI-NP).
Discriminant functional analysis showed that the sensitivity (81%) and specificity (53%) was same for both H-MTR and H-V in separating the NE from the MCI at time-1. However by including the MMSE score, the sensitivity and specificity of the H-MTR increased to 100% (89% for H-V) and 58% (57% for H-V) respectively.
While seperating MCI-P and MCI-NP, the H-MTR had a higher specificity (94%) and sensitivity (70%) compared to H-V, 88% and 60% respectively. The positive predictive value (proportion of MCI with a positive test who would develop AD) was 88% for H-MTR and 75% for H-V. The negative predictive value (proportion of MCI with a negative test who would remain stable) was 83% for H-MTR and 78% for H-V.
Among the MR imaging methods, when compared to the traditional volumetric analysis, MTR is a more sensitive and specific measure to separate NE from the MCI and also for distinguishing between the MCI progressors and non-progressors.
Support: Alz-Can, CIHR.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
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