Neuroscience 2000 Abstract
| Presentation Number: | 279.12 |
|---|---|
| Abstract Title: | Magnetic resonance imaging and spectroscosy identifies structural and biochemical changes after MPTP-induced Parkinson's disease in cats. |
| Authors: |
Podell, M.*1
; Neff, N.2
; Hadjiconstantinou, M.2,3
1Dept Veterinary Clin Sci, Ohio State Univ, Columbus, OH 2Pharmacology , Ohio State Univ, Columbus, OH 3Psychiatry, Ohio State Univ, Columbus, OH |
| Primary Theme and Topics |
J. Disorders of the Nervous System and Aging - 131. Degenerative disease: Parkinson's |
| Secondary Theme and Topics | J. Disorders of the Nervous System and Aging<br />- 132. Degenerative disease: other |
| Session: |
279. Degenerative disease: Parkinson's--clinical II Poster |
| Presentation Time: | Monday, November 6, 2000 11:00 AM-12:00 PM |
| Location: | Hall G-J |
| Keywords: | PARKINSON, MPTP, BASAL GANGLIA, SPECTROSCOPY |
The cause of the chronic nigrostriatal degeneration in Parkinson’s disease (PD) remains unknown. The ability to study ongoing degeneration in vivo over a condensed time period in an animal model offers an opportunity to study potential mechanisms and markers of PD. The purpose of this study was to determine striatal magnetic resonance imaging (MRI) and spectroscopy (MRS) changes after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment in cats. Six adult, specific-pathogen free, male cats were divided into 2 equal groups. Three control cats received saline daily (1 ml/kg SC) while 3 cats received MPTP (5 mg/kg SC) for 10 consecutive days. Pargyline, a MAO inhibitor, was given concurrently (35-50 mg/kg SC) to one MPTP cat (MPTP+PG). Baseline and post-treatment measurements included neurologic examinations, sensory evoked potentials, MRI and proton MRS studies of the basal ganglia. Striatal tissue was collected for histopathologic and neurochemical analysis. MPTP alone treated cats demonstrated bradykinesia, head tremor, and abnormal sensory evoked potential activity. A diffuse increase in T2 signal was seen in the basal ganglia of one MPTP cat. Proton MRS changes included a reduction below the control 95% confidence interval in NAA:CR (neuronal marker) and CHO:CR, as well as the presence of lactate in both MPTP cats, but not the MPTP+PG cat. Histopathologic changes included neuronal necrosis and dropout and astrocytosis in MPTP treated cats. Microhemorrhage with positive ferritin staining was seen in one MPTP cat. Neurochemical analysis is pending. These studies demonstrate that proton MRS is a sensitive measure of neuronal injury and biochemical alteration of the basal ganglia in a feline model of PD.
Supported by PHS grants MH1400 (MP) and NS34571 (NN and MH)
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2000 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2000. Online.
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