Neuroscience 2001 Abstract
| Presentation Number: | 243.7 |
|---|---|
| Abstract Title: | Neural signal changes to inspiratory loading challenges in obstructive sleep apnea revealed by functional magnetic resonance imaging (fMRI). |
| Authors: |
Macey, K. E.*1
; Macey, P. M.1
; Henderson, L. A.1
; Woo, M. A.2
; Frysinger, R. C.1
; Harper, R. K.1
; Valderama, C.1
; Alger, J. R.3
; Harper, R. M.1
1Department of Neurobiology, University of California Los Angeles, Los Angeles, CA 2School of Nursing, University of California Los Angeles, Los Angeles, CA 3Department of Radiological Sciences , University of California Los Angeles, Los Angeles, CA |
| Primary Theme and Topics |
Autonomic, Limbic and Other Systems - Autonomic -- Respiratory regulation |
| Secondary Theme and Topics | Autonomic, Limbic and Other Systems<br />- Biological Rhythms and Sleep |
| Session: |
243. Autonomic: respiratory regulation--rhythm generation and motor output Slide |
| Presentation Time: | Monday, November 12, 2001 9:30 AM-9:45 AM |
| Location: | Room 30C |
| Keywords: | RESPIRATION, CEREBELLUM, FRONTAL CORTEX, CINGULATE |
Obstructive sleep apnea (OSA) is precipitated by atonia of the upper airway muscles and is characterized by extreme loading of airflow, marked diaphragmatic efforts, excessive thoracic and upper airway negative pressures, and significant changes in blood pressure and heart rate. In addition to anatomical factors that enhance obstruction, neural mechanisms that maintain upper airway patency appear defective in the syndrome. We examined the time course of signal changes in neural sites recruited during a challenge approximating the extreme constriction of the airway in OSA, i.e., marked inspiratory loading. A series of 20 image slices (25 repetitions, Echo Planar technique) through the entire brain of 12 male OSA patients (29-59 yrs) and 8 control subjects (29-62 yrs) was collected during 1 min baseline and 1.5 min inspiratory loading challenges in a GE 1.5T Signa scanner. Images collected during baseline and challenge conditions were subjected to a fixed effects analysis using the SPM imaging package. Regions-of-interest were followed for extent of change over the course of the challenge. The OSA group showed significantly larger signal changes within multiple areas, including cerebellum, interpeduncular region, medial cingulate and frontal cortex. We speculate that enhanced activity in affected areas contribute to exaggerated suppression of upper airway muscles during inspiratory loading, and that comparable mechanisms may operate in OSA.
Supported by Supported by NHLBI HL-60296.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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