Neuroscience 2001 Abstract
| Presentation Number: | 243.6 |
|---|---|
| Abstract Title: | BRAIN ACTIVATION DURING A COLD PRESSOR CHALLENGE IN OBSTRUCTIVE SLEEP APNEA (OSA) PATIENTS REVEALED BY FUNCTIONAL MAGNETIC RESONANCE IMAGING. |
| Authors: |
Harper, R. M.*1
; Macey, P. M.1
; Macey, K. E.1
; Woo, M. A.3
; Henderson, L. A.1
; Frysinger, R. C.1
; Harper, R. K.1
; Valderama, C.1
; Alger, J. R.2
1Dept Neurobiol, UCLA, Los Angeles, CA 2Radiological Sciences, UCLA, Los Angeles, CA 3School of Nursing, UCLA, Los Angeles, CA |
| Primary Theme and Topics |
Autonomic, Limbic and Other Systems - Autonomic -- Respiratory regulation |
| Secondary Theme and Topics | Autonomic, Limbic and Other Systems<br />- Biological Rhythms and Sleep |
| Session: |
243. Autonomic: respiratory regulation--rhythm generation and motor output Slide |
| Presentation Time: | Monday, November 12, 2001 9:15 AM-9:30 AM |
| Location: | Room 30C |
| Keywords: | BLOOD PRESSURE, RESPIRATION, CEREBELLUM, HIPPOCAMPUS |
The propensity for transient elevation of blood pressure to suppress diaphragmatic muscle activity, and, preferentially, upper airway muscle tone, suggests a mechanism by which an airway already compromised by anatomical features might be placed at risk for complete obstruction in OSA patients, namely exaggerated somatomotor suppression by pressor challenges. We examined signal changes in neural sites recruited during a cold pressor challenge to the forehead. A series of 20 image slices (25 repetitions, Echo Planar technique) through the brain of 7 male OSA patients (43-59 yrs) and 6 control subjects (29-59 yrs) was collected during 1 min baseline and 1.5 min application of a bag of cold (3oC) deuterium oxide to the forehead in a GE 1.5T Signa scanner. Images collected during baseline and challenge conditions were subjected to a fixed-effects analysis using the SPM imaging package. Both control and OSA subjects showed significantly increased signals in multiple areas, including the caudate nucleus, hippocampus, and ventrolateral frontal cortex. However, signal changes were remarkably enhanced in the lateral cerebellum, periaqueductal gray, and hippocampus of OSA cases over controls. Several of these latter areas have been previously implicated in modulating blood pressure changes in normal conditions, and may mediate exaggerated suppression of upper airway muscle tone to a pressor challenge, thus enhancing conditions for OSA.
Supported by NHLBI HL-60296
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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