Neuroscience 2005 Abstract
| Presentation Number: | 195.9 |
|---|---|
| Abstract Title: | Maturation of the Rhesus monkey primate corpus callosum: a structural MRI study. |
| Authors: |
Payne, C. D.*1
; Machado, C. J.1
; Jackson, E. F.
; Bachevalier, J.1
1Dept Psychology, Yerkes National Primate Research Ctr., Emory Univ., Atlanta, GA |
| Primary Theme and Topics |
Cognition and Behavior - Animal Cognition and Behavior -- Cognitive learning and memory systems |
| Secondary Theme and Topics | Development<br />- Development of Motor Systems |
| Session: |
195. Cognitive Learning and Memory Systems: Primate, Episodic-Like, and Semantic-Like Memory Poster |
| Presentation Time: | Sunday, November 13, 2005 8:00 AM-9:00 AM |
| Location: | Washington Convention Center - Hall A-C, Board # LL12 |
| Keywords: |
The development of the corpus callosum (CC) in rhesus monkeys was investigated using non-invasive magnetic resonance imaging (MRI) techniques. Eleven infant and juvenile monkeys (6 males, 5 females) were scanned in the coronal and sagittal planes using a T-1 weighted imaging sequence from 5 to 115 weeks of age. Also, five adult male monkeys (3-7 years) were scanned using identical procedures. The midsagittal image was used to identify the CC. The CC was segmented into seven subregions (rostrum, genu, rostral body, anterior midbody, posterior midbody, isthmus, and splenium) as described by Witelson, et al. (Brain, 1989, 112:799). Using the Image J software, the surface area of each segment was measured and summed to provide total midsagittal CC surface. Total brain volume (TBV) was also calculated by measuring the surface area of coronal sections at 5mm intervals through the entire brain. CC data, either uncorrected or corrected for TBV, were analyzed for linear maturational trends for both males and females separately. When corrected for TBV, there was a highly significant linear increase in the total CC from 5-115 weeks in males (p=.01) but not females (p>.4). Similarly, the genu, rostral body, anterior midbody, posterior midbody, isthmus, and splenium exhibited linear trends in males (p<=.04), whereas females only exhibited linear trends in the rostral body, anterior midbody and splenium (p<=.05) when the data were uncorrected. No sex differences were observed across any segment when corrected for TBV, although, when not corrected, males showed significantly larger total CC, genu, anterior midbody, isthmus, and splenium than females (p<=.03). Data in animals aged 80 to 120 weeks were grouped and compared to those of adult animals. These comparisons did not show any group differences for either total CC or all segments, indicating that an adult-like CC size is obtained by 1-2 years of age in monkeys.
Supported by MH58846, HD 35471
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
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