Neuroscience 2001 Abstract
| Presentation Number: | 219.13 |
|---|---|
| Abstract Title: | Interobserver reliability in measurement of the hippocampal complex by image analysis. |
| Authors: |
Campbell, S. L.*1
; Amano, S.2
; Pope, H.2
; MacQueen, G. M.1
; Nahmias, C.1,2
1Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Canada 2Radiology, McMaster University, Hamilton, Canada |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Psychiatric Disorders -- Other |
| Session: |
219. Psychiatric disorders: other Poster |
| Presentation Time: | Sunday, November 11, 2001 1:00 PM-2:00 PM |
| Location: | Exhibit Hall ZZ-18 |
| Keywords: | MRI, IMAGING |
The hippocampus has been implicated in a number of disorders including depression, schizophrenia and Alzheimer's disease. Analysis of hippocampal volume using magnetic resonance imaging (MRI) is emerging as a mainstream technique. The purpose of this study was to analyse the interobserver reliability in determining hippocampal volume using MRI. Contiguous 1.2 mm thick, T1 weighted, 3D fast spoiled gradient echo images were obtained. To calculate the total cerebral volume (TCV) and the volume of the hippocampus, the region was traced on each saggital slice, thus determining area in mm2. The TCV includes all white and grey matter within the dura mater, pituitary, pons, medulla and cerebellum. The structures included in the hippocampal complex are the cornu ammonis, dentate gyrus, subiculum, but not the alveus. The measured areas were summed, then multiplied by a slice thickness of 1.2 mm to give the volume in mm3 for each region. The measurements taken by two observers, S1 and S2, were compared. TCV measured by S1 had a mean of 1.35x106 (standard deviation (SD)=1.35x105). TCV measured by S2 had a mean of 1.38x106 (SD=1.27x105). Both were high as compared to Sheline (1999), however we included the brainstem in our measurements while the Sheline group did not. Hippocampal volumes measured by S1 (left: Mean=2935, SD=365, right: Mean=2949, SD=415) and S2 (left: Mean=2833, SD=393, right: Mean=2810, SD=409) were consistent with those of other researchers (Vakili (2000), Sheline (1999, 2000)). The compared observers showed greater than 90% reliability with each other. This technique is a reproducible way to determine hippocampal volumes.
Supported by CIHR
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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