Neuroscience 2000 Abstract
| Presentation Number: | 210.12 |
|---|---|
| Abstract Title: | Functional magnetic resonance imaging during cold pressor challenges in congenital central hypoventilation syndrome. |
| Authors: |
Yu, P. L.*1
; Kim, A. H.1
; Kuo, L.1
; Saeed, M. M.4
; Alger, J. R.3
; Woo, M. A.1
; Gozal, D.1,4
; Keens, T. G.1,4
; Harper, R. M.1,2
1Neurobiology, UCLA Sch Med, Los Angeles, CA 2Brain Res. Inst., UCLA Sch Med, Los Angeles, CA 3Radiological Sci., UCLA Sch Med, Los Angeles, CA 4Ped. Pulmonology, Childrens Hosp. L.A., Los Angeles, CA |
| Primary Theme and Topics |
E. Endocrine and Autonomic Regulation - 66. Cardiovascular regulation: central control |
| Secondary Theme and Topics | E. Endocrine and Autonomic Regulation<br />- 69. Respiratory regulation |
| Session: |
210. Respiratory regulation: chemoreception I Slide |
| Presentation Time: | Monday, November 6, 2000 10:45 AM-11:00 AM |
| Location: | Room 383 |
| Keywords: | BLOOD PRESSURE, DEVELOPMENT, CEREBELLUM, LIMBIC |
In addition to CO2 insensitivity and reduced drive to breathe during sleep, CCHS patients often show impaired responses to transient blood pressure elevation. In adult man, fMRI studies indicate that the brain regions recruited for blood pressure regulation are extensive. We examined fMRI signal changes to a cold pressor challenge in selected brain sites of 7 CCHS children (3 male pairs, 8-15 yrs), ventilator-dependent only during sleep, no Hirschsprung's Disease) and in 7 age- and gender-matched controls. A series of 20 image slices (25 repetitions, Echo Planar technique) through the entire brain was collected during baseline and during application of a cold bag of deuterium oxide to the forehead. Baseline images were subtracted from experimental conditions, and the resultant difference images were subjected to multiple paired t-tests with Bonferroni correction (p<0.01) using MedX software. Brain areas responsive to the cold pressor challenge in controls included sites within the cerebellum, frontal cortex, and limbic system. The CCHS group was characterized by minimal activation in several sites, especially in the amygdala, hippocampus and vermis. We conclude that in children, multiple brain areas, such as limbic and cerebellar structures, are responsive to cold pressor challenges, and that these regions show reduced responses in CCHS patients.
Supported by HD-36228, HD-22695, PSDP-K12-HD-00850
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2000 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2000. Online.
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