Neuroscience 2000 Abstract
| Presentation Number: | 206.3 |
|---|---|
| Abstract Title: | Early social stress and genetic risk factors for prefrontal asymmetries in monkeys: evidence from structural magnetic resonance imaging. |
| Authors: |
Lyons, D. M.*1
; Afarian, H.1
; Yang, C.1
; Sawyer-Glover, A.2
; Schatzberg, A. F.1
1Dept Psychiatry & Behav Sci, Stanford Univ Med Sch, Stanford, CA 2Dept Radiology, Stanford Univ Med Sch, Stanford, CA |
| Primary Theme and Topics |
I. Neural Basis of Behavior - 116. Stress |
| Secondary Theme and Topics | J. Disorders of the Nervous System and Aging<br />- 140. Neuropsychiatric disorders |
| Session: |
206. Stress Slide |
| Presentation Time: | Monday, November 6, 2000 8:30 AM-8:45 AM |
| Location: | Room 287 |
| Keywords: | NEONATAL STRESS, EMOTION, PREFRONTAL MATURATION, LATERALIZATION |
Prefrontal anomalies in psychiatric disorders are often preceded early in life by disruptions in parental care. Genetic risk factors may play an equally influential role as revealed by the human twin-study approach. To test for genetic and social effects on prefrontal cortical volumes in squirrel monkeys, this study combined a paternal half-sibling analysis with three postnatal conditions that altered aspects of early maternal care. In one condition, offspring were periodically removed from natal groups between 13-21 weeks of age. Differences in maternal availability were produced in two other conditions by manipulating the effort required to find food. Whole brain T1-weighted 3D-FSPGR images were obtained 3-5 years later from all 39 young adults. Significantly larger right than left prefrontal volumes were discerned, although left and right cerebral hemispheric measures did not differ. Both genetic and postnatal rearing related differences were evident in the right but not left prefrontal cortex. Asymmetric vulnerabilities in prefrontal cortex may reflect neural mechanisms in postnatal development linking social stress and genetic risk factors with psychopathology in adulthood.
Supported by the Nancy Pritzker Network and MH47573.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2000 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2000. Online.
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