Neuroscience 2004 Abstract
Presentation Number: | 145.10 |
---|---|
Abstract Title: | Magnetic resonance T2 relaxometry in patients with congenital central hypoventilation syndrome. |
Authors: |
Kumar, R.*1
; Macey, P. M.1
; Woo, M. A.2
; Harper, R. M.1,3
1Neurobiology, UCLA USA, Los Angeles, CA 2CA, Depart Neurobiol, 90095-1763, 3USA, Depart Neurobiol, 90095-1763, |
Primary Theme and Topics |
Homeostatic and Neuroendocrine Systems - Respiratory regulation |
Secondary Theme and Topics | Homeostatic and Neuroendocrine Systems<br />- Cerebral Blood Flow and Homeostasis<br />-- Hypoxia/Hyperoxia |
Session: |
145. Respiratory Regulation I Slide |
Presentation Time: | Sunday, October 24, 2004 10:15 AM-10:30 AM |
Location: | San Diego Convention Center - Room 28D |
Keywords: | RESPIRATION, CARDIOVASCULAR, BRAIN, HYPOXIA |
Congenital Central Hypoventilation Syndrome (CCHS) patients exhibit reduced ventilatory responses to CO2 and hypoxia, loss of breathing drive during sleep, and a variety of autonomic nervous system-related aberrations. The breathing deficiencies contribute to intermittent hypoxic exposure. Magnetic Resonance imaging (MRI) using T2 relaxometry allows for assessment of tissue integrity and is more reliable for this purpose than routine MRI. Proton density (PD) and T2- weighted images were collected on 11 CCHS and 28 age- and gender- matched controls using a 3.0 Tesla scanner; high resolution T1- weighted images were also collected. Pixel- by- pixel T2 maps were generated using the PD and T2-weighted images. Data were analyzed using SPM2 and Matlab-based custom software. High resolution T1-weighted images were normalized to Montreal Neurological Institute space templates, and the resulting parameters were applied to T2 maps; these normalized T2 maps were smoothed. Two-sample t-tests were performed at each voxel to compare T2 values of control and CCHS groups, and statistical parametric maps showing regions of significant T2 value changes were displayed (corrected for multiple comparisons; p < 0.05). No sites showed higher values in control compared with CCHS subjects. CCHS cases showed significantly higher T2 values in cerebellar cortex, fastigial nucleus, frontal cortex bordering the anterior cingulate, posterior and mid cingulate cortices, thalamus extending to basal ganglia, and posterior temporal cortex, suggesting abnormalities within these sites. The structures may have been damaged by repeated hypoxic exposure, and the particular sites may contribute to some of the aberrant cardiovascular and respiratory patterns observed in the syndrome.
Supported by NICHD-HD-22695
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
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