Neuroscience 2002 Abstract
| Presentation Number: | 181.5 |
|---|---|
| Abstract Title: | Evaluation of working memory development in childhood using functional magnetic resonance and diffusion tensor imaging. |
| Authors: |
Thomason, M. E.*1
; Cooper, J.1
; Race, E. A.1
; Bammer, R.1
; Gabrieli, J. D. E.1
1Neurosciences Department, Stanford University, Stanford, CA |
| Primary Theme and Topics |
Cognition and Behavior - Human Cognition and Behavior -- Executive function: Working memory |
| Secondary Theme and Topics | Cognition and Behavior<br />- Human Cognition and Behavior<br />-- Learning and memory |
| Session: |
181. Human cognition and behavior: working memory I Poster |
| Presentation Time: | Sunday, November 3, 2002 1:00 PM-2:00 PM |
| Location: | Hall A2-B3 P-18 |
| Keywords: | working memory, children, fMRI, DTI |
The goal of this study was to examine the neural correlates of the maturation of working memory. We compared neural activity during working memory task performance between children (8-12 years old) and young adults. Previous investigations of young adults have demonstrated hemispheric asymmetries in the organization of verbal and spatial memory. Verbal working memory tasks are frequently related to activation in Broca's area, supplementary motor cortex, premotor cortex, dorsolateral prefrontal cortex, anterior cingulate, and parietal cortex of the left hemisphere. Spatial working memory, however, predominately activates homologous regions of the right hemisphere. Older adults, who have reduced working memory capacity, show less asymmetry than young adults. A question of interest, therefore, was whether children would also show reduced asymmetry. We collected functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) data from adults and children using a 3 Tesla GE scanner in a Sternberg, delay-match-to-sample, paradigm. Load (the amount of information maintained in working memory and modality (verbal or spatial) were varied to evaluate the effect of increasing task demands, and domain-specificity of working memory, respectively. Functional data was spatially registered with diffusion tensor images, with morphological reference to high-resolution anatomical images. Differences in neural activation between children and adults were evaluated.
Supported by MH61426-01
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2002 Neuroscience Meeting Planner. Orlando, FL: Society for Neuroscience, 2002. Online.
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