Neuroscience 2004 Abstract
| Presentation Number: | 22.11 |
|---|---|
| Abstract Title: | Baseline cerebral blood flow using continuous arterial spin labeling (CASL) perfusion magnetic resonance imaging (MRI) in asymptomatic, mild cognitive motor deficit (MCD), and aids dementia (ADC). |
| Authors: |
Roc, A. C.*1
; Ances, B. M.1
; Okawa, J.2
; Wang, J.1
; Kolson, D. L.1
; Detre, J. A.1
1Dept Neurol., Univ Pennsylvania, Philadelphia, PA 2Dept Infectious Dis., Univ Pennsylvania, Philadelphia, PA |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Brain Blood Flow, Metabolism, and Homeostasis -- Functional Imaging |
| Session: |
22. Blood Flow I Slide |
| Presentation Time: | Saturday, October 23, 2004 3:30 PM-3:45 PM |
| Location: | San Diego Convention Center - Room 28D |
| Keywords: | CD4, viral load, neuropsychiatric |
The exact mechanisms involved in cognitive impairment that occurs with AIDS is unclear. Neuropsychological testing is often performed to assess deficits, however, non-invasive measurements of cerebral blood flow may allow for detection of deficits prior to abnormal neuropsychological results. Early diagnosis and treatment may lead to improvement. CASL MRI is a non-invasive tool that follows tissue and microvasculature perfusion of arterial water. 32 HIV patients and 6 controls underwent neuropsychological evaluation and were rated on the HIV dementia scale by Power (10 asymptomatic, 14 MCD, 8 ADC). Patients had laboratory results (CD4+, viral load, hemoglobin, hematocrit) taken within 2 months of the scan. Images were obtained on a Siemens 3.0T scanner using a standard quadrature head coil and imaging protocol which includes an axial rapid gradient echo followed by a CASL perfusion sequence. Global resting perfusion (GRP) and resting perfusion (RP) within the perforating branches of arterial circulation was calculated. Vascular regions of interest for RP were normalized to a common template. T-tests were performed between GRP and RP vs CD4+ , viral load, and Power dementia scale. No significant differences were seen between GRP and RP within the vascular distributions for controls compared to asymptomatic, MDC, or ADC patients. Neither CD4+ nor viral load affected GRP or RP within the vascular distributions. These results suggest an uncoupling between neuronal activity, as measured by neuropsychiatric scores, and baseline blood flow. Quantitative measurements of cerebral blood flow through CASL, CD4+ or viral load are not predictive in detecting early AIDS associated cognitive changes. These results may help in determining the introduction of antiretroviral therapy.
Supported by Center for AIDS Research
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
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