Neuroscience 2002 Abstract
| Presentation Number: | 159.10 |
|---|---|
| Abstract Title: | In vivo visualization of interhemispheric functional connections in cat visual cortex. |
| Authors: |
Kim, M.*1
; Ronen, I.1
; Kim, K. H.1
; Formisano, E.2
; Ugurbil, K.1
; Goebel, R.2
; Kim, D. S.1
1Center for Magnetic Resonance Research, University of Minnesota Medical School, Minneapolis, MN 2Department of Neurocognition, University of Maastricht, Maastricht, The Netherlands |
| Primary Theme and Topics |
Sensory Systems - Vision -- Striate visual cortex: Functional organization and circuitry |
| Session: |
159. Visual cortex: connectivity and organization Poster |
| Presentation Time: | Sunday, November 3, 2002 2:00 PM-3:00 PM |
| Location: | Hall A2-B3 F-64 |
| Keywords: | Cat visual cortex, fMRI, DTI, in vivo anatomy |
For an integrated understanding of the brain’s functional architecture, in vivo correlation between functional areas and the pattern of neuronal connectivity is necessary. Such correlation studies were difficult to perform in the past, as most anatomical techniques necessitated invasive or terminal procedures. In the present study, we used the technique of the Diffusion Tensor Magnetic Resonance Imaging (DT-MRI) in combination with high-resolution functional MRI in cat primary visual cortex. Retinotopic organization of the both hemispheres of the cat visual cortices was obtained using standard stimuli. We used 9.4T magnet (30 Gauss/cm). MR parameters for fMRI: gradient-echo Echo-Planar Imaging; TE=15ms; TR=150ms; 64x64 in a FOV of 3x3 cm2, resolution: 460x460 mm2/pixel. Parameters for DT-MRI: spin-echo EPI; TE=44ms; TR=1000ms; 128x128 in a FOV of 5x5 cm2, resolution: 200x200 mm2/pixel. Diffusion parameters were: d=6ms, D=16ms, g=17g/cm (b=1040s/mm2). Diffusion-weighted images were obtained for 6 gradient encoding directions. Custom-written software was used for fiber tracing and visualization. Turbo-FLASH based multi-slice anatomical data set were displayed either as flat or spherical maps. Subsequently, fMRI and DTI tracing data were overlaid on the flat and spherical maps. This unique framework enabled us – for the first time – the relationship between retinotopic representation and the interhemispheric connections through corpus callosum to be visualized in a completely non-invasive manner.
Supported by NIH (RR08079), the Keck Foundation, and the HFSP.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2002 Neuroscience Meeting Planner. Orlando, FL: Society for Neuroscience, 2002. Online.
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