Neuroscience 2005 Abstract
| Presentation Number: | 101.1 |
|---|---|
| Abstract Title: | A case of neuromyelitis optica (NMO) with extensive brain stem involvement. |
| Authors: |
Vendrame, M.*1
; Azizi, S. A.1
1Dept Neurology, Temple Univ., Philadelphia, PA |
| Primary Theme and Topics |
Disorders of the Nervous System - Demyelinating Disorders -- Human studies and animal models |
| Secondary Theme and Topics | Disorders of the Nervous System<br />- Neurodegenerative and Movement Disorders<br />-- Other |
| Session: |
101. Multiple Sclerosis: Human and Animal Poster |
| Presentation Time: | Saturday, November 12, 2005 1:00 PM-2:00 PM |
| Location: | Washington Convention Center - Hall A-C, Board # TT29 |
| Keywords: | DEMYELINATION, MULTIPLE SCLEROSIS, MRI, BRAIN STEM |
NMO (or Devic syndrome) is a demyelinating disease characterized by the concomitant presence of optic neuritis and myelitis. Since its first characterization, it has been controversial whether NMO should be considered as a subtype of multiple sclerosis (MS) or for its clinical and topographical characterization it should be regarded as a distinct nosological entity. NMO affects specifically the optic nerve and the spinal cord without involvement of the brain. MRI scans of the spinal cord usually show extensive lesions (extending over 3 segments), while brain MRI are generally normal. We report a case of NMO with atypical clinical and neuroimaging findings. Initial clinical presentation, neuroimaging studies, CSF analysis, and presence of NMO IgG autoantibodies confirmed the diagnosis of NMO. However, our patient also demonstrated clinical involvement of brain stem. Magnetic Resonance imaging demonstrated extensive lesions within the medulla, pons and optic radiations. The spectrum of clinical and radiological presentation of NMO is discussed.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
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