Neuroscience 2004 Abstract
| Presentation Number: | 1030.19 |
|---|---|
| Abstract Title: | Screening and characterizing atypical and typical antipsychotics with magnetic resonance imaging and 3D computational analyses. |
| Authors: |
Sullivan, R. W.*1
; Febo, M.1
; Kulkarni, P.1
; King, J. A.1
; Ferris, C. F.1
1Psych Behav Molec Neurosc, UMASS-Medi Sch, Worester, MA |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Behavioral Pharmacology -- Other |
| Secondary Theme and Topics | Neurological and Psychiatric Conditions<br />- Psychiatric Disorders<br />-- Other |
| Session: |
1030. Behavioral Pharmacology II Poster |
| Presentation Time: | Wednesday, October 27, 2004 3:00 PM-4:00 PM |
| Location: | San Diego Convention Center - Hall A-H, Board # FFF18 |
| Keywords: | fMRI, schizophrenia, antipsychotics, dopamine |
Functional MRI in conscious animals provides a new opportunity in drug discovery to identify patterns of brain activity characteristic of different classes of psychotropic molecules. To this end, rats were tested with functionally different classes of drugs used to treat schizophrenia - atypical (clozapine, respiridone) and typical (chlorpromazine, haloperidol) antipsychotics. Rats showed a dose-dependent (change in brain activity dominated by negative BOLD signal) within 10-15 min of iv injection of drug. Since the efficacy of these drugs is related, in part, to their affinity for dopamine receptors, animals were challenged with an ICV injection of apomorphine following neuroleptic treatment. While several areas of the brain were activated by apomorphine administration alone, the most robust increase in BOLD signal intensity occurred in the prefrontal cortex. The typical antipsychotics, haloperidol and chlorpromazine blocked the action of apomorphine in the prefrontal cortex, while respiradol and clozapine had little or no effect on dopamine activity in this brain area. The data are discussed in the context of the different subclasses of dopamine receptors, their binding affinities for each neuroleptic, and their distribution in the brain. This work was supported by a grant from NIMH MH052280.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
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