Neuroscience 2004 Abstract
| Presentation Number: | 1022.6 |
|---|---|
| Abstract Title: | Caudate nucleus volume and its clinical and cognitive correlates in female neuroleptic-naive patients with schizotypal personality disorder. |
| Authors: |
Koo, M.*1,2
; Levitt, J. J.1,2
; McCarley, R. W.1
; Seidman, L. J.1
; Dickey, C. C.1,2
; Niznikiewicz, M. A.1
; Voglmaier, M. M.1
; Zamani, P.1
; Long, K. R.2
; Kim, S. S.1
; Shenton, M. E.1,2
1Dept of Psychiatry, Harvard Med. Sch., Brockton, MA 2SPL, at BWH, Harvard Med. Sch., Brockton, MA |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Psychiatric Disorders -- Schizophrenia--Pathology |
| Session: |
1022. Schizophrenia: Functional Deficit IV Poster |
| Presentation Time: | Wednesday, October 27, 2004 2:00 PM-3:00 PM |
| Location: | San Diego Convention Center - Hall A-H, Board # AAA12 |
| Keywords: | CAUDATE, MRI, COGNITION |
Objective: The caudate may contribute to psychopathological, cognitive deficits in Schizotypal personality disorder (SPD), a schizophrenia spectrum disorder. We also focused on the female as there is evidence to suggest that cognition and psychopathology may differ according to gender in schizophrenia spectrum disorder. Here we examine using Magnetic resonance imaging (MRI) caudate nucleus volume change and cognitive deficits in a sample of female SPD who had no previous neuroleptic exposure and controls.
Method: MRI scans obtained on a 1.5 T magnet with 1.5-mm contiguous slices were used to measure the caudate nucleus in 32 right-handed, neuroleptic-naive female subjects with SPD and in 29 normal comparison female subjects. Subjects were group matched for age, parental socioeconomic status and IQ.
Results: First, we found significantly lower right and left relative caudate volume (7.6%, 8.4%) in female SPD than in female normal subjects. Second, there were significant, inverse correlations between right relative volume and positive symptoms (magical thinking, suspiciousness, psychotic like symptoms) and between total relative volume and negative symptoms (affective flattening). Third, we found significant inverse correlations between total relative volume and nonperseveration error in Wisconsin Card Sorting test and positive correlations between scores in California Verbal Learning Test in SPD.
Conclusion: These data are consistent with the findings of reduced caudate nucleus volume reported in studies of neuroleptic-naive first episode schizophrenia and in our prior study of male SPD. The significant correlations support the association of intrinsic pathology in the caudate nucleus with psychopathological and cognitive abnormality in a schizophrenia spectrum disorder, SPD.
Method: MRI scans obtained on a 1.5 T magnet with 1.5-mm contiguous slices were used to measure the caudate nucleus in 32 right-handed, neuroleptic-naive female subjects with SPD and in 29 normal comparison female subjects. Subjects were group matched for age, parental socioeconomic status and IQ.
Results: First, we found significantly lower right and left relative caudate volume (7.6%, 8.4%) in female SPD than in female normal subjects. Second, there were significant, inverse correlations between right relative volume and positive symptoms (magical thinking, suspiciousness, psychotic like symptoms) and between total relative volume and negative symptoms (affective flattening). Third, we found significant inverse correlations between total relative volume and nonperseveration error in Wisconsin Card Sorting test and positive correlations between scores in California Verbal Learning Test in SPD.
Conclusion: These data are consistent with the findings of reduced caudate nucleus volume reported in studies of neuroleptic-naive first episode schizophrenia and in our prior study of male SPD. The significant correlations support the association of intrinsic pathology in the caudate nucleus with psychopathological and cognitive abnormality in a schizophrenia spectrum disorder, SPD.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
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