Neuroscience 2003 Abstract
| Presentation Number: | 941.16 |
|---|---|
| Abstract Title: | Functional MRI of conscious marmosets following oral MDMA. |
| Authors: |
Brevard, M. E.*1
; Meyer, J. S.2
; Ferris, C. F.1
1CCNI, Univ. of MA Med. Sch, Worcester, MA 2MA, 55 Lake Ave N, 01655, |
| Primary Theme and Topics |
Cognition and Behavior - Animal Cognition and Behavior -- Learning & memory: Pharmacology |
| Secondary Theme and Topics | Neurological and Psychiatric Conditions<br />- Behavioral Pharmacology<br />-- Other |
| Session: |
941. Learning & Memory: Pharmacology VI Poster |
| Presentation Time: | Wednesday, November 12, 2003 4:00 PM-5:00 PM |
| Location: | Morial Convention Center - Hall F-I, Board # K10 |
| Keywords: | SENSORY, DRUG ABUSE, PRIMATE, VISUAL CORTEX |
MDMA, or Ecstasy, is a widely used recreational drug with potent effects on cognition and behavior and possible long term effects on brain function, chemistry, and anatomy. Recent MRI studies have looked at CBF changes, NAA levels, and tissue diffusion changes in human MDMA users.
In this experiment, conscious marmosets were acclimated to the MRI and imaged in a restrainer (Insight Neuroimaging Sys.) in a 4.7T MRI (Bruker). The initial period of drug uptake was imaged while evoked sensory activity was assessed prior to, and following oral MDMA (1mg/kg).
Globally, BOLD signal decreased after drug administration. Activations were seen after 20-40 minutes in dopaminergic/serotonergic regions of the brain, chiefly: caudate, putamen, globus pallidus, and nucleus accumbens. Preliminary data suggest that visual activations were slightly lower after MDMA while somatosensory activations remained consistent (see figure). No major changes in respiratory physiology were noted during the experiment.
Initial findings suggest that the visual system may be affected by acute MDMA administration.These data are the first to demonstrate functional effects of MDMA in awake, nonhuman primates given a clinically relevant dose of MDMA by a naturalistic route of administration.
In this experiment, conscious marmosets were acclimated to the MRI and imaged in a restrainer (Insight Neuroimaging Sys.) in a 4.7T MRI (Bruker). The initial period of drug uptake was imaged while evoked sensory activity was assessed prior to, and following oral MDMA (1mg/kg).
Globally, BOLD signal decreased after drug administration. Activations were seen after 20-40 minutes in dopaminergic/serotonergic regions of the brain, chiefly: caudate, putamen, globus pallidus, and nucleus accumbens. Preliminary data suggest that visual activations were slightly lower after MDMA while somatosensory activations remained consistent (see figure). No major changes in respiratory physiology were noted during the experiment.
Initial findings suggest that the visual system may be affected by acute MDMA administration.These data are the first to demonstrate functional effects of MDMA in awake, nonhuman primates given a clinically relevant dose of MDMA by a naturalistic route of administration.
Supported by NIDA-DA13517
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2003 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2003. Online.
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