Neuroscience 2001 Abstract
| Presentation Number: | 970.6 |
|---|---|
| Abstract Title: | LATE REVERSAL OF CEREBRAL PERFUSION AND WATER DIFFUSION AFTER FOCAL ISCHEMIA IN RATS STUDIED BY MAGNETIC RESONANCE IMAGING AT 9.4 TESLA. |
| Authors: |
Yushmanov, V. E.*1
; Wang, L.1
; Liachenko, S.1
; Tang, P.1,2
; Xu, Y.1,2
1Department of Anesthesiology/CCM, University of Pittsburgh School of Medicine, Pittsburgh, PA 2Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Cerebral Blood Flow |
| Secondary Theme and Topics | Neurological and Psychiatric Conditions<br />- Ischemia<br />-- Cellular and molecular mechanisms |
| Session: |
970. Cerebral blood flow III Poster |
| Presentation Time: | Thursday, November 15, 2001 9:00 AM-10:00 AM |
| Location: | Exhibit Hall WW-55 |
| Keywords: | MCAO, CEREBRAL BLOOD FLOW, DELAYED RESPONSE, NEUROIMAGING |
Region-specific cerebral blood flow (CBF) and apparent diffusion coefficient (ADC) of water in the rat brain were quantified by high-field MRI (9.4 T) for 6-7 hours and up to 5 days after middle cerebral artery occlusion (MCAO), either in the permanent occlusion mode or during reperfusion after 85 min of MCAO. Upon occlusion, average CBF fell from ~1.5-2 ml/g/min to <0.5 ml/g/min in cortical areas and to <0.2 ml/g/min in the caudoputamen (CP). CBF in the homologous contralateral areas also decreased by 25-30%. Corresponding ADC decreases were most profound in the CP and parietal cortex (from ~8 × 10−4 to 5 × 10−4 mm2/s), lesser in the frontal cortex, and negligible in the piriform cortex, suggesting that the perfusion threshold for ADC decrease may be different for different brain regions in the same animal. On average, CBF recovered only to ~30% of the baseline in the first 24 h of reperfusion. After 3-4 days of reperfusion, however, CBF and ADC changes were reversed: a strong hyperperfusion in the ipsilateral hemisphere, up to ~2 ml/g/min in CP and 4 ml/g/min in the cortex, was observed. The relative ADC intensities in the ipsi- and contra-lateral CP were also inverted. This change may reflect the impairment to auto-regulation in the ischemic regions. A better understanding of the mechanisms of CBF and ADC reversal in the late stage of reperfusion may prove useful in characterizing the degree of tissue damage, and in developing and evaluating treatment strategies.
Supported by NINDS, NIH: R01NS36124.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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