Neuroscience 2004 Abstract
| Presentation Number: | 902.15 |
|---|---|
| Abstract Title: | Increased medial temporal lobe activation in mild cognitive impairment: A functional-anatomic MRI study. |
| Authors: |
Dickerson, B. C.*1,4
; Salat, D. H.2
; Greve, D. N.2
; Rand-Giovannetti, E.1
; Driscoll, A.4
; Chua, E.4
; Rentz, D.4
; Blacker, D.3
; Albert, M. S.1,3,5
; Sperling, R. A.1,4
1Dept. Neurol., Massachusetts Gen. Hosp./Harvard Med Sch., Charlestown, MA 2Dept. Radiology, Massachusetts Gen. Hosp./Harvard Med Sch., Charlestown, MA 3Dept. Psychiatry, Massachusetts Gen. Hosp./Harvard Med Sch., Charlestown, MA 4MA, Gerontology Research Unit, 02129, 5USA, Gerontology Research Unit, 02129, |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Neurodegenerative Disorders -- Alzheimer's Disease: Cognitive function |
| Secondary Theme and Topics | Cognition and Behavior<br />- Human Cognition, Behavior, and Anatomy<br />-- Learning and long-term memory |
| Session: |
902. Dementia: Pathobiology Poster |
| Presentation Time: | Wednesday, October 27, 2004 10:00 AM-11:00 AM |
| Location: | San Diego Convention Center - Hall A-H, Board # UU8 |
| Keywords: | memory, Alzheimer, functional MRI, hippocampus |
Functional magnetic resonance imaging (fMRI) was used to study memory-associated activation of medial temporal lobe (MTL) regions in 3 groups: cognitively intact elderly controls (n=10), individuals with mild cognitive impairment (MCI, n=9), and patients with probable Alzheimer’s disease (AD, n=10). Subjects performed a face-name associative encoding task during fMRI scanning, and were tested for recognition of stimuli afterward. High-resolution structural and fMRI data were acquired with a 3T scanner. Two approaches were used to analyze MRI data: statistical parametric mapping of group mean activation and differences between groups, and a functional-anatomic method in which fMRI activation was quantified within MTL regions of interest identified from each individual’s structural MRI. Despite clinical evidence of a history of decline in memory function, MCI subjects performed similarly to controls on the fMRI memory task (85% and 87%, p=0.6); AD patients performed significantly worse (66%, p<0.005). In the MCI group (compared to controls), both analytic methods revealed significantly greater MTL activation while there was no difference in MTL volumes (e.g., hippocampal vol, p=0.61). In contrast, the AD group showed both MTL atrophy and a lesser degree of activation. Taken together with similar findings on a picture-encoding task in a separate MCI sample from our lab, these results support the hypothesis that there may be a phase of increased MTL activation in prodromal AD, which may represent a pathophysiologic marker or a compensatory response to maintain memory performance.
Supported by NIA PO1-AG04953, K23-AG22509, NINDS K23-NS02189, Harvard/MIT CITP
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
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