Neuroscience 2004 Abstract
| Presentation Number: | 821.1 |
|---|---|
| Abstract Title: | Increasing brain tissue sodium, [Na<sup>+</sup>]<sub>br</sub>, from magnetic resonance imaging (MRI) localizes the ischemic core identified with MAP2 in rat focal cerebral ischemia. |
| Authors: |
Jones, S. C.*1
; Kharlamov, A. N.1
; Yanovski, B.1
; Kanchana, J.1
; Ziolko, S. K.3
; Derbyshire, S. W. G.2
; Boada, F. E.2
; Easley, K. A.4
1Dept Anesthesiol, Allegheny Gen Hosp, Pittsburgh, PA 2PA, 320 E North Ave, 15212-4772, 3USA, 320 E North Ave, 15212-4772, 4MR Res Ctr, Radiology, 320 E North Ave, 15212-4772, |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Ischemia -- Neuroprotection and tolerance |
| Session: |
821. Neuroprotection II Slide |
| Presentation Time: | Wednesday, October 27, 2004 8:00 AM-8:15 AM |
| Location: | San Diego Convention Center - Room 3 |
| Keywords: | BRAIN IMAGING, MCAO, IMMUNOHISTOCHEMISTRY, STROKE |
We propose that the rate of increase of the brain concentration of sodium, [Na+]br, monitored using sodium MRI, can be used to locate the ischemic region in a rat model of cortical ischemia. In four Sprague-Dawley rats, focal cortical ischemia was induced during isoflurane anesthesia and continuous physiological monitoring. Sodium 3D and proton 2D data were acquired on a 3 Tesla whole body scanner (GEMS) using a dual tuned 5 cm diameter coil. [Na+]br time course maps were acquired continuously from 2-7 hr after occlusion. T2-weighted proton images (T2w, see Fig) and MAP2 immuno-stained brain sections were used to verify the location of the infarct (red outline). AMIDE software was used to view, analyze, and register image data, including a parametric image of the rate of [Na+]br increase (color scale). For all four animals the region of maximal [Na+]br increase corresponded to the ischemic region identified with MAP2. [Na+]br increased at a population mean rate of 19 ± 2.4 %/hr in ischemic tissue (p = 0.004), but not in normal cortex. These results of sodium MRI show that the region of maximal [Na+]br increase corresponds to the ischemic region, suggesting that this method can be used as a ticking clock to estimate time elapsed after vascular occlusion independent of ischemic core localization.
Supported by NIH NS 30839
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
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