Neuroscience 2000 Abstract
| Presentation Number: | 833.15 |
|---|---|
| Abstract Title: | Dose-dependent modulation of cerebral motor activity by a serotonin enhancer evidenced by functional magnetic resonance imaging. |
| Authors: |
Loubinoux, I.*1
; Boulanouar, K.1
; Rascol, O.1
; Demonet, J.1
; Manelfe, C.3
; Chollet, F.1,2
1INSERM U455, 31059 Toulouse, France 2Féd de Neurologie, 31059 Toulouse, France 3Sces de Neuroradiologie, 31059 Toulouse, France |
| Primary Theme and Topics |
G. Motor Systems and Sensorimotor Integration - 96. Sensorimotor integration |
| Secondary Theme and Topics | D. Neurotransmitters, Modulators, Transporters, and Receptors<br />- 53. Serotonin |
| Session: |
833. Sensorimotor integration: human studies Poster |
| Presentation Time: | Thursday, November 9, 2000 10:00 AM-11:00 AM |
| Location: | Hall G-J |
| Keywords: | sensorimotor, serotoninergic drug, antidepressant, motor cortex |
Serotonin is involved in motor control. Serotonin re-uptake inhibitors would facilitate motor recovery in post-stroke patients undergoing rehabilitation (Dam M, Stroke, 1996;27:1211-14). Fluoxetine, an inhibitor of serotonin reuptake, was shown to enhance brain motor activation in executive motor areas of healthy subjects (Loubinoux I., JCBF, 1999;19:1365-75). Effects on cerebral motor activity of a single dose (20 or 60 mg against placebo) of paroxetine (Deroxat®) were assessed in 6 healthy subjects. Either 20 mg, or 60 mg or placebo were given in 3 sessions 8 days apart, in a within subject counterbalanced, double-blinded study. 1.5T MRI scanner was used for BOLD imaging. 16 axial images, 5-mm-thick, were acquired every 3 seconds using a T2*-weighted single-shot EPI sequence. 3 runs were acquired during one session. One run consisted of eight 30-second epochs alternating between rest and activation. During activation, subjects were instructed to perform, with the right hand, the auditory 1 Hz-paced task that alternated between 2 fist closings with sequential touch of the thumb with each of the 4 digits. The data were analyzed using SPM96. Paroxetine (20 or 60 mg) elicited similar effects to fluoxetine, a hyperactivation in contralateral S1M1 and posterior SMA, and a cerebellar hypoactivation. Dose and effect were correlated: 20 mg induced greater effects than 60 mg. We demonstrated for the first time that the modulation of brain motor activity by a single dose of paroxetine in healthy subjects is dose-dependent.
Supported by SmithKline Beecham
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2000 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2000. Online.
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