Neuroscience 2001 Abstract
| Presentation Number: | 785.2 |
|---|---|
| Abstract Title: | EVENT-RELATED FUNCTIONAL MAGNETIC RESONANCE IMAGING DURING THE PRESENTATION OF AFFECTIVE IMAGES IN DEPRESSED VERSUS NONDEPRESSED PARTICIPANTS. |
| Authors: |
Putnam, K. M.*1,2
; Mueller, C. J.1
; Schaefer, H.1
; Jahn, A. L.1
; Ng, E. B.1
; Nitschke, J. B.1
; Benca, R. M.2
; Anderle, M. J.1
; Zhang, R.3
; Postle, B.1
; Davidson, R. J.1,2
1Psychology, University of Wisconsin, Madison, WI 2Psychiatry, University of Wisconsin, Madison, WI 3Medical College of Wisconsin, Milwaukee, WI |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Psychiatric Disorders -- Affective Disorders |
| Session: |
785. Psychiatric disorders: mood disorders--human studies II Slide |
| Presentation Time: | Wednesday, November 14, 2001 1:15 PM-1:30 PM |
| Location: | Room 33C |
| Keywords: | AFFECTIVE DISORDER, PSYCHOPATHOLOGY, EMOTION, FUNCTIONAL MRI |
The present study investigated the neural circuitry of affective processing in depression using event-related fMRI. Positive, negative, and neutral affective images were presented sequentially for 3 s, separated by blank screens, while BOLD signal fMRI data were acquired. Six medication-free individuals with Major Depressive Disorder or Dysthymia and six healthy controls viewed 3 runs of 63 different picture presentations. Three different time conditions provided an effective time resolution of 1s. A voxel-by-voxel 2-way (Valence x Group) ANOVA was done to examine percent signal change. Voxels exceeding the significance threshold for the interaction were further tested with planned comparison t-tests that were corrected by the Bonferroni method. Paired t-tests for the significant voxel clusters revealed differences between the negative and the neutral images for the depressed group, p's <.005. Depressed participants showed greater right prefrontal activation (tranverse frontal polar gyrus, superior frontal sulcus, middle frontal gyrus) and greater left midfrontal activation (posterior middle frontal gyrus ) in response to the negative images, in contrast to the neutral images. In response to the negative slides, these brain regions were significantly more activated for the depressed versus the control group, p's <.005.
Supported by NIMH
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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