Neuroscience 2000 Abstract
| Presentation Number: | 749.4 |
|---|---|
| Abstract Title: | Isolation of brain regions associated with deductive reasoning by functional magnetic resonance imaging. |
| Authors: |
Rodriguez Moreno, D.*1
; Kim, K. H. S.1,2
; Hirsch, J.1,2
1Dept. of Neuroscience, Cornell University Weill Medical College, New York, NY 2Dept. of Neurology, MSKCC, New York, NY |
| Primary Theme and Topics |
I. Neural Basis of Behavior - 105. Cognition: higher functions |
| Secondary Theme and Topics | I. Neural Basis of Behavior<br />- 106. Cognition: methods and models |
| Session: |
749. Cognition: higher functions--executive function Poster |
| Presentation Time: | Wednesday, November 8, 2000 4:00 PM-5:00 PM |
| Location: | Hall G-J |
| Keywords: | COGNITIVE*, IMAGING, MAPPING*, PARIETAL CORTEX |
Considerable insight into the architecture of reasoning could be gained by isolating the network of brain areas that supports this essential function. This study employed fMRI and a deductive reasoning task, performed either with visual or auditory stimuli, to identify the modality-independent brain areas associated with reasoning. Anatomical and functional images were acquired on a GE Signa 1.5T scanner equipped for echoplanar imaging. The activation epoch consisted of 10 trials where each trial included the presentation of two arguments and the production of a conclusion. A voxel-by-voxel, multistage statistical analysis and a logical AND operation isolated those voxels that were associated with the task performed in both sensory modalities. A conservation stage identified the supra-modal brain regions that were conserved across all 7 subjects. The pattern of brain regions that subserved reasoning consisted of left inferior frontal gyrus (Brodmann's areas (BA) 44 and 45), medial frontal gyrus (BA 6), and middle frontal gyrus (BA 6 and 9); and bilateral superior and middle frontal gyrus (BA 22 and 21) and inferior parietal lobule (BA 40). The activity was biased towards the left hemisphere even for the areas that presented bilateral activation. Most of these regions, with the exception of BA 40, are thought to represent language and memory-related areas. The presence of a non-language-related area suggests that some processes involved in deductive reasoning are outside of traditional language areas.
Supported by William T. Morris Foundation Fellowship (DRM and KHSK); NIH MSTP Grant (KHSK); Charles A. Dana Foundation, J & J Focused Giving Foundation and Cancer Center Support Grant NCI (JH)
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2000 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2000. Online.
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