Neuroscience 2005 Abstract
| Presentation Number: | 53.20 |
|---|---|
| Abstract Title: | Imaging of hyperalgesia in rats by functional MRI. |
| Authors: |
Hess, A.*1
; Sergejeva, M.1
; Budinsky, L.2
; Zeilhofer, H.1
; Brune, K.2
1Pharmacological Imaging and Image Analysis, I. f. Pharmacology and Toxcicology, Erlangen, Germany 2Innovations in Animal and Consumer Protection, I. f. Pharmacology and Toxcicology, Erlangen, Germany |
| Primary Theme and Topics |
Sensory and Motor Systems - Pain -- Pain imaging and perception |
| Secondary Theme and Topics | Cognition and Behavior<br />- Animal Cognition and Behavior<br />-- Learning and memory: Physiology and imaging |
| Session: |
53. Pain imaging Poster |
| Presentation Time: | Saturday, November 12, 2005 4:00 PM-5:00 PM |
| Location: | Washington Convention Center - Hall A-C, Board # V29 |
| Keywords: | hyperalgesia, rat brain, functional MRI, plasticity |
Cerebral activation in response to contact heat stimulation of the hindpaw was observed in functional magnetic resonance imaging (fMRI) experiments in isoflurane anesthetized rats. Cingulate-, sensory-motor-, and insular cortex, as well as medial and lateral posterior thalamic nuclei, hypothalamus and periaqueductal gray were the most consistently, often bilaterally activated regions. Subcutaneous zymosan injection into one hindpaw led to inflammation and hyperalgesia resulting in activity changes in the namely CNS structures. When the contact heat stimulus was applied after initiating inflammation the hyperalgesia manifested itself as a significant increase of the size of activated areas and/or functional blood oxygenation level dependent (BOLD) signal amplitude in the mentioned brain regions. These changes developed over time and are due to peripheral and central sensitization. Our results indicated that processes of sensitization in the cerebrum led to significant increases not only after stimulation of the injected but also after stimulation of the non injected paw – cerebral sensitization. The latter were significant only in higher, associative brain structures and not in thalamic input structures. Zymosan induced hyperalgesia monitored with high resolution fMRI in anesthetized animals proofs to be an effective alternative model for testing of novel analgesics and assessing their effects on pain processing on identified brain structures along central pain pathways.
Supported by BMBF Kopfschmerz, SET, Doerenkamp Professor for Innovations in Animal and Consumer Protection
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
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