Neuroscience 2005 Abstract
| Presentation Number: | 635.13 |
|---|---|
| Abstract Title: | Functional magnetic resonance imaging during passive foot movement in congenital central hypoventilation syndrome patients. |
| Authors: |
Macey, P. M.*1
; Kumar, R.1
; Woo, M. A.2
; Harper, R. K.1
; Harper, R. M.1
1Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 2School of Nursing, David Geffen School of Medicine at UCLA, Los Angeles, CA |
| Primary Theme and Topics |
Homeostatic and Neuroendocrine Systems - Respiratory Regulation |
| Secondary Theme and Topics | Homeostatic and Neuroendocrine Systems<br />- Cardiovascular Regulation |
| Session: |
635. Respiratory Control: Development, Plasticity, and Disease Poster |
| Presentation Time: | Tuesday, November 15, 2005 8:00 AM-9:00 AM |
| Location: | Washington Convention Center - Hall A-C, Board # BB23 |
| Keywords: | MRI, AUTONOMIC, SLEEP, RESPIRATION |
Although Congenital Central Hypoventilation Syndrome (CCHS) patients show impaired ventilatory responses to CO2 and reduced drive to breathe during sleep, affected patients increase ventilation to passive limb motion, indicating a degree of preserved integration of cyclic locomotor systems with respiration. Functional magnetic resonance imaging (fMRI) procedures can examine the neural processes mediating limb movement integration with respiratory patterns in CCHS. We examined brain fMRI signal changes in 16 CCHS patients and 32 age- and gender-matched control subjects to passive right foot movement. Each fMRI series consisted of 175 volumes over 350 s, with an initial 70 s baseline, three 40 s challenges separated by 40 s rest periods, and ending with 80 s baseline. Images were motion corrected, spatially normalized, and smoothed. Brain regions with altered fMRI responses between groups were determined using SPM2 (boxcar model, random effects, analysis of covariance, age as covariate, threshold P < 0.01), and overlaid onto anatomical images. Multiple regions with similar signal changes, especially in somatosensory cortex, emerged in both groups. However, increased signals developed in control over CCHS subjects in the cerebellar cortex, globus pallidus, ventral putamen, nucleus accumbens, hippocampus, amygdala, hypothalamus, posterior cingulate, and left posterior insular and posterior superior temporal cortices, while isolated areas of cerebellar and parietal cortex increased signals in CCHS over control subjects. Although integration of limb movement with breathing occurs in CCHS patients, the processes partially differ, especially in basal ganglia and limbic sites likely mediating concomitant autonomic patterns with motion.
Supported by NICHD-HD-22695
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
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