Neuroscience 2001 Abstract
| Presentation Number: | 690.9 |
|---|---|
| Abstract Title: | Role of the cerebellum and higher brain centers in the expression of the Bezold-Jarisch as revealed by functional magnetic resonance imaging. |
| Authors: |
Henderson, L. A.*1,2
; Yu, P. L.1
; Frysinger, R. C.1
; Galons, J. P.3
; Harper, R. K.1
; Bandler, R.2
; Harper, R. M.1
1Neurobiology, UCLA, Los Angeles, CA 2Anatomy and Histology, University of Sydney, Sydney, Australia 3Radiology, University of Arizona, Tucson, AZ |
| Primary Theme and Topics |
Autonomic, Limbic and Other Systems - Autonomic -- Cardiovascular regulation |
| Secondary Theme and Topics | Autonomic, Limbic and Other Systems<br />- Autonomic<br />-- Respiratory regulation |
| Session: |
690. Autonomic: cardiovascular regulation--afferents and reflexes Slide |
| Presentation Time: | Wednesday, November 14, 2001 10:00 AM-10:15 AM |
| Location: | Room 25A |
| Keywords: | cardiovascular, respiration, medulla, amygdala |
The Bezold-Jarisch depressor reflex, implicated in myocardial ischemia and aortic stenosis, and possibly in shock sequences, elicits a profound fall in arterial pressure (AP), heart rate (HR) and apnea. The sites and patterning of central neural substrates involved in mediating this reflex remain unclear. Using functional magnetic resonance imaging procedures to examine brain activity, we elicited the Bezold-Jarish reflex via i.v. 5-hydroxytryptamine (5HT) in 9 isofluorane-anaesthetized adult cats (4.7T, TR=8 secs, TE=25 ms, FOV=8 cm, flip angle=90 degrees, voxel dimensions=0.625 x 0.625x2 mm). Intravenous 5HT (10-30mg/kg) evoked a rapid onset fall in AP (mean=20%), HR decline (mean=18%) and a prolonged apnea (mean=25secs). Signal intensity (SI) fell in brainstem cardiovascular regions (nucleus tractus solitarius, caudal and rostral ventrolateral medulla), and also in the caudal midline medulla, multiple regions of the cerebellum (deep nuclei, vermis) and the dorsolateral pons. In contrast, rostral brain sites, including the midbrain periaqueductal gray matter, hypothalamus and amygdala showed late onset increases in SI. Further, increased SI within the hypothalamus and amygdala were lateralized to the right side. Areas of the cerebellum and rostral brain sites play a role in the Bezold-Jarisch reflex in addition to well-described medullary cardiovascular regions, and these areas do so in a lateralized fashion.
Supported by HD-22506, HL-22418, HD (K12-HD00850-PSDP)
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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