Neuroscience 2004 Abstract
| Presentation Number: | 615.9 |
|---|---|
| Abstract Title: | Functional magnetic resonance imaging of rodent somatosensory cortex during postnatal development. |
| Authors: |
Colonnese, M. T.*4
; Constantine-Paton, M.2,3,4
; Jasanoff, A.1,3,4
1Nuclear Engin., MIT, Cambridge, MA 2Biol., MIT, Cambridge, MA 3BCS, MIT, Cambridge, MA 4McGovern Inst., MIT, Cambridge, MA |
| Primary Theme and Topics |
Development - Development of Sensory and Limbic Systems -- Somatosensory system |
| Secondary Theme and Topics | Sensory Systems<br />- Tactile/Somatosensory<br />-- Cortex imaging |
| Session: |
615. Development: Somatosensory System Poster |
| Presentation Time: | Tuesday, October 26, 2004 8:00 AM-9:00 AM |
| Location: | San Diego Convention Center - Hall A-H, Board # F21 |
| Keywords: | BOLD, FORELIMB , RAT |
Application of fMRI techniques to the study of developmental plasticity first requires characterization of the heamodynamic response in young rats. To this end we are examining the developmental changes in the temporal and spatial patterns of activation caused by a characterized somatosensory stimulus, the forepaw shock, in neonatal and juvenile rats. Immobilization is provided by low-level isoflurane anesthesia. Functional imaging is performed at 4.7T using blood oxygenation level dependent (BOLD) contrast, as well as changes in cerebral blood volume (CBV) monitored by injection of blood pool contrast agents. In response to a 10 second epoch of paw shock, pups examined 20 or 30 days after birth show adult-like BOLD signal that is strongest in the contralateral primary somatosensory cortex. Further experiments will show the youngest age at which robust BOLD or CBV changes can be observed, and if there is evidence for refinement of the functional connectivity underlying somatosensory processing at these ages.
Supported by Whitehead Institute, McGovern Institute for Brain Research
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
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