The cerebral areas involved in audition and vision in the awake rhesus monkey (Macaca mulatta) were identified with the 2-[14C]deoxyglucose (2-DG) method (Poremba et al., SFN Abstr. 25:571.18, 1999; Macko et al., Science 218:394-7,1982). Glucose utilization was determined in intact hemispheres and in hemispheres deafferented from auditory or visual input during auditory or visual stimulation. The experimental groups consisted of 1) monkeys with unilateral auditory deafferentation achieved by unilateral ablation of the inferior colliculus together with transection of the corpus callosum, and the anterior, posterior, and tectal commissures; and 2) monkeys with unilateral visual deafferentation achieved by unilateral optic tract cut with transection of the corpus callosum and the anterior commissure. Animals in the first group passively listened to a wide variety of auditory stimuli and in the second group passively viewed visual stimuli during the 2-DG uptake period of 45 minutes. The results delineate the b...