A major limitation of functional Magnetic Resonance Imaging (fMRI) is its relatively weak spatial specificity. The Blood-Oxygenation-Level-Dependent (BOLD) response to stimulus presentation often spreads to neighboring non-active brain tissue — the resp...

Anorexia nervosa is an eating disorder characterized by restrictive caloric intake that induces profound weight loss. The neurobiology of this disorder is unknow, but magnetic resonance imaging studies reported functional and structural alterations in t...

A 3D seeded region growing technique was applied to MRI images of the spinal cord in order to separate morphological features such as gray and white matter. This technique was implemented to overcome the problems in delineating boundaries between morphologic structures using standard clinical MRI scans (T1, T2, continuous slice) of the spinal cord. Traditional images are 256 levels of gray with no clear delineation between white matter and gray matter tracts. Threshold based segmentation techniques, which are typically used for the identification of morphologic boundaries, are not adequate for this problem due to the nature of the MRI images. Small pockets of supposed white matter appear in gray matter and vice versa. The 3D seeded region growing technique takes advantage of both inter-slice and intra-slice variations in gray level to segment gray and white matter and insure that the regions are contiguous. This eliminates the pockets that would occur if a simple threshold were used. Once segmented, the da...

Blood-oxygen-level-dependent signal (BOLD) as measured with functional magnetic resonance imaging (fMRI) arises principally from two physiologic factors underlying BOLD: cerebral blood flow (CBF), which quantifies the rate of oxygen delivery to metaboli...

Introduction The efficacy of cognitive behavioral therapy (CBT) for chronic pain has been demonstrated across clinical trials. However, there are few resting-state functional magnetic resonance imaging (rs-fMRI) studies. We used the intrinsic connectivi...

The white matter contains long-range connections between different brain regions. Tractometry uses diffusion-weighted magnetic resonance imaging (dMRI) data to quantify tissue properties along the trajectories of these connections in the human brain in ...

Mapping functional location of the primary somatosensory cortex (S1) is necessary for understanding of the properties of tactile perception in human. Generally, the ultra-high field functional magnetic resonance imaging (fMRI) could provide the reliable...

The human brain is extremely flexible and capable of rapidly selecting relevant information in accordance with task goals. Functional magnetic resonance imaging (fMRI) studies have shown that multiple demand (MD) regions in frontoparietal cortex flexibl...

Background: It is unclear how each subfield within the hippocampus (HC) contributes to memory function. Animal studies indicate positive correlations between HC neurogenesis and learning performance. However it is uncertain whether this association is d...

To clarify the neural substrates and their dynamics during crossmodal association learning, we conducted functional magnetic resonance imaging (MRI) during audiovisual paired-association learning of delayed matching-to-sample tasks. Thirty subjects were involved in the study; 15 performed an audiovisual paired-association learning task, and the remainder completed a control visuo-visual task. Each trial consisted of the successive presentation of a pair of stimuli. Subjects were asked to identify predefined audiovisual or visuo-visual pairs by trial and error. Feedback for each trial was given regardless of whether the response was correct or incorrect. During the delay period, several areas showed an increase in the MRI signal as learning proceeded: crossmodal activity increased in unimodal areas corresponding to visual or auditory areas, and polymodal responses increased in the occipitotemporal junction and parahippocampal gyrus. This pattern was not observed in the visuo-visual intramodal paired-associa...