Functional magnetic resonance imaging (fMRI) has provided intriguing insights into the topography and functional organization of visual cortical areas in the human brain. However, little is known about the functional anatomy of subcortical nuclei. Here, we used high-resolution fMRI (1.5 × 1.5 × 2 mm3) at 3 tesla to investigate the retinotopic organization of the human lateral geniculate nucleus (LGN). The central 15° of the visual field were mapped using periodic flickering checkerboard stimuli that evoked a traveling wave of activity. The contralateral visual hemifield was represented with the lower field in the medial-superior portion and the upper field in the lateral-inferior portion of each LGN. The horizontal meridian was significantly overrepresented relative to the vertical meridian. The fovea was represented in posterior and superior portions, with increasing eccentricities represented more anteriorly. The magnification of the fovea relative to the periphery was similar to that described for human...

Electroacupuncture (EA) affects the neurophysiology in overweight/obese populations, curbing appetite and decreasing cravings. Our study evaluated overweight/obese Chinese patients' responses to a food-cue functional-magnetic-resonance-imaging (fMRI) ta...

Background and objectives: Few studies focused on the abnormal phase modulation of the time-frequency analysis in functional magnetic resonance imaging (fMRI) blood oxygenation level dependent (BOLD) signal in schizophrenia. The present research aimed t...

Popular for its ability to non-invasively image the macroscopic anatomical and functional connections in the brain, functional magnetic resonance imaging (fMRI) of the human cortex has revealed promising results concerning the reliability and stability ...

If attention is divided during learning, memory suffers. Nevertheless, individuals can learn information with divided attention. This event-related functional magnetic resonance imaging (fMRI) study ( n = 17) investigated what neural processes support (1) learning with divided attention and (2) retrieval of information learned with divided attention. Participants encoded words (Is the word abstract or concrete?) while performing an auditory discrimination task (press a button whenever an auditory pattern changes). The auditory task was easy or hard, depending on the similarity of the patterns. A behavioral study indicated that detailed (“recollective”) information was more likely to be present for words encoded with the easy versus the hard concurrent task. Words encoded with the hard versus the easy concurrent task, in contrast, were more likely to rely on less detailed (“familiarity”-based) information. fMRI revealed encoding-related activation in the left prefrontal cortex (PFC) and left hippocampus tha...

Mobility is a strong predictor of institutionalisations, falls, quality of life and mortality in older adults. More recently, mobility has also been linked to cognitive functioning. The association between mobility measures and brain structure, however,...

Functional magnetic resonance imaging in macaques offers the opportunity to assess whole-brain activity in a species that is amenable to recording and neuronal manipulation. We developed a novel tool set for imaging awake rhesus macaques at resolutions ...

Different functional neuroimaging modalities are currently used for in-vivo studies of brain function and dysfunction. While blood-oxygen- level-dependent functional magnetic resonance imaging (BOLD-fMRI) currently provides neuroscientists with the high...

The amygdala (AMY) is a key brain region of the limbic system that plays a critical role in emotion processing and stress response. Functional magnetic resonance imaging (fMRI) studies identified abnormal amygdala (AMY) activation in psychiatric illness...

Pupose: This study was done to determine whether diffusion MRI (dMRI) can detect neuroprotective and regenerative effects of fibroblasts secreting brain derived neurotrophic factor (Fb-BDNF) in the white matter (WM) of the spinal cord following injury. Materials and Methods: Unmodified fibroblasts (Fb-UM) (N=2) or Fb-BDNF (N=2) were placed in a hemisection cavity. Sacrifice was at 1 or 8 weeks. Following perfusion fixation, dMRI was performed. Apparent diffusion coefficients (ADC's) parallel and perpendicular to the long axis of the cord were obtained in the rubrospinal tract (RST) where prior research has shown that Fb-BDNF transplants provide neuroprotection and promote axonal regeneration. Results: At 1 week, Fb-UM and Fb-BDNF ADC's in WM were similar, however abnormal as compared to control. At 8 weeks, ADC's rostral to the transplant were near normal in Fb-BDNF, while remaining abnormal in Fb-UM. The anisotropy index, abnormal in Fb-UM and Fb-BDNF at 1 week, was near normal rostral in Fb-BDNF by 8 wee...