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  • Abstract
    III. Clinical trial data demonstrating sedative-hypnotic efficacy of the α3-subunit preferring GABAA receptor partial allosteric activator, NG2-73: Translational validity of pharmacokinetic/pharmacodynamic (PK/PD) relationships derived from preclinical studies
    NG2-73 is a partial allosteric activator at the benzodiazepine (BZD) site associated with GABAA receptor complexes, with greatest intrinsic activity at receptors containing α3-subunits1. NG2-73 shows sedative-like actions in animal models2 and, based on...
    Nov 6, 2007
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