When trained on a T-maze that can be solved using either a hippocampus-dependent place strategy or striatum-dependent response strategy, rats tend to use a place strategy during the initial learning, but later shift to a response strategy (Packard & McGaugh, PNAS, 1996). The switch in strategy is coincident with increases in acetylcholine (ACh) release in hippocampus and striatum observed during training (Chang & Gold, SFN, 2000). Glucose (16.7 nmol) or aCSF (Ns=10) was injected bilaterally into the hippocampus of male rats prior to training on the T-maze (105 trials). To assess strategy, probe trials were included after every 15th training trial. Glucose enhanced acquisition to a criterion of 9/10 correct (p<.005). A key question was whether enhancement of learning by intrahippocampal glucose would be accompanied by delay or acceleration of the switch from place to response strategy. Nine of the ten glucose-treated rats began their sequence of criterion trials prior to the first probe trial. The glucose-t...