Glucoprivation triggers a sympathoadrenal response that results in hyperglycemia. In rats, repeated bouts of glucoprivation result in an impaired hyperglycemic response (Ritter, SFN Abstract p. 614,1999). It is possible that the factors that impair the hyperglycemic response also inhibit reproduction. In Syrian hamsters, systemic treatment with 2-deoxy-D-glucose (2DG) (1750 mg/kg) every 6 h on days 1 and 2 of the estrous cycle induced anestrus and impaired the hyperglycemic response to glucoprivation. Plasma glucose concentrations [Pglu] were significantly increased compared to saline-treated controls in 2DG-treated hamsters after the first (166±12.75 mg/dl), but not after the fifth 2DG injection (117±8.32 mg/dl). 5-thio-D-glucose (5TG), the glucose analog preferred for central treatment, was administered to the fourth ventricle (ICV) by either acute infusion (300 μg/3μl) every 6 h on days 1 and 2, or via minipumps that delivered 1μl/h (100 μg/μl) on days 4, 1 and 2 of the estrous cycle. Similar to 2DG tre...