VP025 (Vasogen Inc.) is a preparation of phospholipid microparticles containing phosphatidylglycerol, shown to exert anti-inflammatory effects in brain and to abrogate lipopolysaccharide- and age-induced up-regulation of IL-1β and IL-1β-induced signalling (Martin et al.,SFN abstracts 2004, 904.8). Here we assessed the effect of VP025 on changes induced by a single intracerebroventricular injection and chronic administration of β-amyloid. In one study, groups of 8 young male Wistar rats were injected intramuscularly with either 150µl of saline or VP025 (1.2 x 107 particles/ml) on days 14, 13 and 1 before assessing their ability to sustain long-term potentiation (LTP). On day 0, urethane-anaesthetized rats were injected intracerebroventricularly (icv) with (5µl) saline or β-amyloid (200µM), and 3 hours later were assessed for LTP in perforant path-granule cell synapses. In a second study, groups of 6 rats were similarly pre-treated with saline or VP025. These animals were anaesthetized to allow implantation ...