Cognitive reappraisal is an emotion regulation strategy that involves influencing emotions by changing thinking. In prior work (SFN abstract Q-31, 2002), the use of cognitive reappraisal to up-regulate, or increase, emotional responses was demonstrated to involve left prefrontal activity similar to cognitive down-regulation. However, the precise effects of the prefrontal activations seen in cognitive up-regulation on other aspects of emotional responding have yet to be specified. The goal of the present fMRI study was to map the relations between the prefrontal cortex and autonomic and experiential channels of emotion responding in cognitive up-regulation of negative emotion. Twenty-four participants were asked to reappraise photos by increasing their self-involvement with events depicted in negatively emotionally arousing photos. Results suggest that the effects of cognitive up-regulation on autonomic and experiential channels depend upon relations between the prefrontal cortex, cingulate and bilateral am...