Separate regions of the dentate nucleus project via the thalamus to motor and non-motor areas of the cerebral cortex (Dum & Strick, J Neurophysiol. 2003). Consistent with the results of anatomical studies, we previously showed that the motor core of the dentate is functionally activated in monkeys performing reaching movements (Picard and Strick, SFN Abstr. 2002). Here, we extend our analysis to compare relative levels of activation in the motor region of the dentate during performance of internally-guided movements and during performance of similar movements guided by vision. We examined the patterns of 2-deoxyglucose (2DG) uptake in the cerebellum of monkeys trained to perform either sequential reaching movements to visual targets (Random task), or learned sequences of reaching movements performed without visual cues (Repeating task) for liquid rewards. Other animals simply licked liquid rewards but did not perform arm movements. In the dentate nucleus, comparable patterns of activation related to reward...