Most reports of Parkinson’s disease indicate that males have a higher prevalence. This can be studied within the laboratory as sex differences are present within animal models of Parkinson’s disease. We have reported that female mice show a higher striatal Dopamine (DA) uptake and decreased 3,4-dihydroxyphenylacetic acid (DOPAC) production as compared to male mice suggesting a gender difference in vesicular functioning. (SFN 2003 Poster #706.10) To further analyze these gender differences in the vesicular transporter mechanisms, we infused different concentrations of Reserpine (10µM, 20µM or 50µM) during superfusion of male (n=4) and female (n=4) corpus striatum tissue. After a three-interval basal collection period, the Reserpine solution was infused for a two collection interval period. The normal superfusion medium was resumed with the start of collection interval five and continued until the termination of the superfusion at collection interval eight. The amount of DA obtained in effluent samples follo...