PKA-RIIbeta-/- mice, despite compensatory upregulation of PKA-RI subunits, display little or no ocular dominance plasticity (ODP; Fischer et al., 2002, SFN abstr 820.9). We hypothesized that this occurs because RII subunits localize PKA to relevant substrates through binding with an A-kinase anchoring protein (AKAP). To test this hypothesis we examined ODP in: normal wild type, contralaterally deprived wild type, contralaterally deprived RIIbeta-/-, contralaterally deprived RIIalpha-/-, and contralaterally deprived AKAP150-/- mice. On postnatal day 24 (P24) deprived mice underwent monocular lid suture. Between P28-33 extracellular single-unit recordings were made in all mice to determine the weighted ocular dominance (WOD) scores of cells in several penetrations made across the medial-lateral extent of binocular V1. Genotypes were confirmed by PCR. WOD scores in contralaterally deprived RIIbeta-/- mice were significantly different from those in contralaterally deprived, but not normal wild type mice. In co...