Neural activity at the large-scale population level has been suggested to be consistent with a sequence of brief, quasi-stable spatial patterns. These “microstates” and their temporal dynamics have been linked to myriad cognitive functions and brain diseases. Most of this research has been performed using EEG, leaving many questions unaddressed, such as the existence, dynamics, and behavioral relevance of microstates at the level of local field potentials (LFP). Here, we adapted the standard EEG microstate analysis to triple-area LFP recordings from 192 electrodes in rats, in order to investigate the mesoscopic dynamics of neural microstates within and across brain regions during novelty exploration. We performed simultaneous recordings from the prefrontal cortex (PFC), striatum (STR), and ventral tegmental area (VTA) in male rats during awake behavior (object novelty and exploration). We found that the LFP data can be accounted for by multiple, recurring, microstates that were stable for ∼60-100 ms. The ...