Hypoxic-ischemic (HI) cerebral injury in the perinatal period leads to significant neurodevelopmental disability in surviving children. Magnetic resonance imaging (MRI) is currently the most accurate method of assessing the nature of such cerebral injur...

Rationale: temporal lobe epilepsy (TLE) is frequently associated with hippocampal atrophy that can be detected by magnetic resonance imaging (MRI). Atrophic hippocampus of TLE patients is characterized by neuronal loss and reorganization of vesicular zi...

Dysfunction of the Na+/K+ ATPase of chronically demyelinated axons is thought to contribute to the continuous and irreversible neurological decline that occurs during the latter stages of multiple sclerosis (MS). In this study, we determined the distrib...

Previous research has shown a developmental decrease in impulsive choice across adolescence that is diminished or absent in youth who engage in binge drinking. Further, magnetic resonance imaging (MRI) has shown lateral regions of the prefrontal cortex ...

We report on MRI data from a subject who experienced a spontaneous visual aura during resting state functional magnetic resonance imaging (rsfMRI). Data was acquired immediately prior to onset of migraine with aphasia and hemiplegia. The mechanisms unde...

Acute, binge, and chronic alcohol exposure have distinct effects on the brain. Although the effects of acute ethanol (EtOH) exposure on various magnetic resonance imaging (MRI) metrics have been evaluated in humans, systematic evaluations of the effects...

We compared psychophysical and functional magnetic resonance imaging (fMRI) responses within areas V1-V3 and MT+ during both a speed and a contrast discrimination task. We found that fMRI responses did not depend significantly on task in any of these areas. Moreover, responses in V1-V3 were larger than those in MT+ for both the speed and the contrast discrimination tasks across a wide range of contrasts. This pattern of results demonstrates that localizing function based on finding those regions of cortex that show greater activity to a given task-stimulus combination than to other tasks and stimuli may, under certain conditions, be misleading. However, a simple ideal observer model assuming that perceptual thresholds are dependent on neuronal population responses does successfully show that V1 has neuronal properties consistent with our subjects' contrast discrimination performance, and that MT+ has neuronal properties consistent with subjects' performance on a speed discrimination task.

Introduction: While animal studies have populated much of our knowledge about the histopathologic sequelae of spinal cord injury (SCI), empirical studies of human spinal cords after traumatic injury are comparatively rare. Furthermore, past human studie...

Ischemic Stroke (IS) is the third most common cause of death affecting 15 million people each year worldwide. Magnetic resonance imaging (MRI) allows non-invasive in vivo evaluations of stroke volume (SV), edema and perfusion. However, reliable computat...

Huntington’s disease (HD) is a genetic neurodegenerative disorder due to an abnormally expanded CAG triplet repeat region in the HTT gene. Magnetic resonance imaging (MRI) has been used to better understand the pathogenesis and progression of HD, but ha...