BACKGROUNG Magnetic resonance imaging (MRI)-based atlases have become widely available for the human and mouse brain, allowing quantitative image analysis on a large scale in clinical and preclinical studies. Unlike rodents, the pig brain is gyrencephal...

Arterial spin labeling (ASL) is a noninvasive magnetic resonance imaging (MRI) technique that uses magnetically labels arterial blood to obtain estimates of cerebral blood flow (CBF) and bolus arrival time (BAT). Yet, to date, its application to the stu...

The third trimester through the neonatal period is characterized by rapid brain growth. However, longitudinal magnetic resonance imaging (MRI) studies of fetal brain volume have been limited. Increased understanding of normal, fetal brain growth could h...

The good coverage and high resolution afforded by functional magnetic resonance imaging (fMRI) make it an excellent tool for the noninvasive imaging of the human brain. Equally interesting, however, is the use of this technique in animal studies using high magnetic fields. In the latter case, highly

Background: Acquiring resting-state functional magnetic resonance imaging (fMRI) datasets on more than one MRI scanner and at multiple clinical sites can increase the overall sample size, which may improve statistical power and generalizability of the r...

Restricted, repetitive behavior is diagnostic for autism spectrum disorder (ASD) and a prominent feature of other neurodevelopmental disorders. Magnetic resonance imaging (MRI) has been widely used to study ASD, but with relatively little focus on the d...

To date neuroanatomical connections have been mainly examined by means of degeneration methods and tracing techniques. Such studies require fixed processed tissue for the data analysis, and therefore they cannot be applied on the live animal. In the present study, we examined the neuronal connections in-vivo, particularly the output connections of striatum using MRI visible contrast agent (MnCl2) that is transported anterogradely through the axon, and subsequently trans-synaptically. MnCl2 (0.8 M) was injected into the caudate nucleus, and putamen in two rhesus monkeys. After the injection, the axonal transport of MnCl2 was continuously monitored for 24 hr or 45 hr using a 4.7T Biospec (Bruker, Inc) NMR scanner. We found a clear signal enhancement in the external and internal segments of the globus pallidus (Gpe and Gpi, respectively), and the substantia nigra, 24h after MnCl2 injection into the head of the caudate nucleus or putamen. Consistent with the previous anatomical studies, the spatial distributio...

Organophosphorus compounds (OPs) are a class of highly toxic substances that includes a number of pesticides as well as the deadly nerve agents soman, sarin, tabun and VX. Multiple mechanisms of action, including the irreversible inhibition of acetylcho...

The symptoms of Alzheimer's disease (AD) arise from neurodegeneration of specific vulnerable regions of the brain. Using high-throughput automated computational analysis of in vivo magnetic resonance imaging (MRI) data, we investigated AD-related cortic...

INTRODUCTION: Surgical treatment for temporal lobe epilepsy is highly effective when clinicians can correlate the location of structural and functional abnormalities in a patient [1]. Magnetic Resonance Imaging (MRI) is the favored neuroimaging method f...