White matter hyperintensities (WMHs) are a neurological feature of magnetic resonance imaging (MRI) that are clinically associated with an increased risk of stroke and dementia. WMHs represent regions of myelin and axon rarefaction, however, changes in ...

Cerebrospinal fluid (CSF) and blood flow through the brain, driven by the cardiac pulse cycle. Several noninvasive magnetic resonance imaging (MRI) methods can measure typical and atypical fluid dynamics, but techniques need further improvement to rapid...

We measured brain activity, perceptual thresholds, and reading performance in a group of dyslexic and normal readers to test the hypothesis that dyslexia is associated with an abnormality in the magnocellular (M) pathway of the early visual system. Functional magnetic resonance imaging (fMRI) was used to measure brain activity in conditions designed to preferentially stimulate the M pathway. Speed discrimination thresholds, which measure the minimal increase in stimulus speed that is just noticeable, were acquired in a paradigm modeled after a previous study of M pathway-lesioned monkeys. Dyslexics showed reduced brain activity compared with controls both in primary visual cortex (V1) and in several extrastriate areas, including area MT and adjacent motion-sensitive areas (MT+) that are believed to receive a predominant M pathway input. There was a strong three-way correlation between brain activity, speed discrimination thresholds, and reading speed. Subjects with higher V1 and MT+ responses had lower per...

Major depressive disorder (MDD) is a severe mental illness characterized by low mood, anhedonia, and often associated with heightened anxiety. Human magnetic resonance imaging (MRI) studies have described structural alterations in key brain regions invo...

Parkinson’s disease (PD) is a chronic and progressive neurodegenerative disease characterised by the loss of dopaminergic (DA) neurons in the substantia nigra (SN) (Shulman et al., 2011). Previous magnetic resonance imaging (MRI) studies investigating t...

Background and Purpose: Aggregation of alpha-synuclein (aSyn) is the hallmark pathology for multiple neurodegenerative diseases such as Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). The objective of this study was to test how MRI-based b...

Cerebral white matter hyperintensities (WMH) measured by magnetic resonance imaging (MRI) are associated with vascular risk factors and are thought to reflect small vessel disease. Recently, Kern et al. (2017), used a multivariate technique, the Scaled ...

Neural activity evoked by brief stimulation creates changes in cerebral blood flow (CBF) and oxygen uptake that together create the hemodynamic response functional response (HRF). We used arterial spin labeling (ASL) magnetic resonance imaging (MRI) to ...

The identification of structural changes in the brain on magnetic resonance imaging (MRI) scans is increasingly important in the study of neurological and psychiatric diseases. MRI can be used to identify and exclude treatable causes of cognitive impairment and it has also become important in the

Background: Magnetic resonance imaging (MRI) volumetric and postmortem studies suggest hippocampal involvement in the pathophysiology of major depression. Deficits in this stress-sensitive structure have been linked to both the cognitive and emotional c...