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of 33803 results
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AbstractMany studies have shown that certain physical activity (PA) produces changes in the hippocampus that correlate with improved cognitive performance. However, current studies have not examined the association between PA performed in different habitual con...Oct 20, 2019
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AbstractSensory and affective responses can be shaped by multiple ingredients such as sensory and conceptual information, social and affective values, past memories, relevance to the ‘self’, etc. All these ingredients construct affective meaning, which could dr...Oct 20, 2019
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Parkinson’s disease (PD) is a progressive neurodegenerative disease that is typically diagnosed late in its progression. There is a need for biomarkers suitable for monitoring the disease progression at earlier stages to guide the development of novel neuroprotective therapies. One potential biomarker, α-synuclein, has been found in both the familial cases of PD, as well as the sporadic cases and is considered a key feature of PD. α-synuclein is naturally present in the retina, and it has been suggested that early symptoms of the visual system may be used as a biomarker for PD. Here, we use a viral vector to induce a unilateral expression of human wild-type α-synuclein in rats as a mechanistic model of protein aggregation in PD. We employed functional magnetic resonance imaging (fMRI) to investigate whether adeno-associated virus (AAV) mediated expression of human wild-type α-synuclein alter functional activity in the visual system. A total of 16 rats were injected with either AAV-α-synuclein ( n = 7) or ...May 1, 2021
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AbstractBrain [Na+] has been proposed to assess insult duration in evolving stroke (Wang et al, 2000 Stroke 31,1386). Stroke localization and the type of local blood supply may modify this relation. We hypothesized that the time course of [Na+] in cortical stroke (COR) where collateral circulation is present is different than in caudoputamen stroke (CP) where collateral circulation is absent. In Sprague-Dawley rats (~340 g) under isoflurane anesthesia focal ischemia was induced either by occlusion of the distal middle cerebral artery and both common carotid arteries or by insertion of an intraluminal suture through the internal carotid artery. 3D [Na+] data were obtained on a 3 T whole body scanner (GE MS) using a dual-tuned (23Na/1H), dual-quadrature birdcage RF coil. The infarct was located using ADC 1H images. [Na+] maps (twisted projection) were acquired every 5.3 min from which the [Na+] in % change from the average in normal cortex was measured vs. time after occlusion, Ta, in hours. The rate of [Na+] increa...Nov 9, 2003
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AbstractIn our hypoxia-ischemia induced cerebral palsy animal model, acute changes in apparent diffusion coefficient (ADC) in fetal brain during uterine ischemia predicts which fetuses will become hypertonic. There is a ‘normal’ ADC threshold and only fetuses w...Nov 7, 2007
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AbstractExperience-driven changes of sensory inputs cause reorganization of cortical sensory maps in the adult brain. Our lab postulated that down-regulation of Nogo receptor (NgR) is one prerequisite for structural reorganization of synaptic circuitry. However...Nov 7, 2007
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AbstractLocomotion or passive foot motion increases respiratory rate and tidal volume, a relationship of interest as a means to stimulate breathing for patients with sleep-disordered breathing, especially children with hypoventilation disorders. To determine th...Nov 4, 2007
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AbstractBackground and purpose- In humans, it has been demonstrated that neural substrates for tactile shape discrimination display a right-sided asymmetry. Right handed tactile object recognition has also been shown to result in predominantly right-sided neura...Nov 3, 2007
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AbstractRecently, decoding emotions from brain activity signals has been drawn attentions to develop better communication tools based on computer devices. However, most existing studies focus on emotions elicited by passively viewing of emotional images or reco...Nov 14, 2017
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AbstractThe extent to which time duration is represented in associate memory remains under-investigated. We designed a time paired associate task (TPAT) in which participants implicitly learnt cue-time-target associations between cue-target pairs and specific c...Nov 13, 2017