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1601 - 1610 of 33803 results
  • Abstract
    Physical activity context correlates with hippocampal subfield and nuclei of the amygdala volume
    Many studies have shown that certain physical activity (PA) produces changes in the hippocampus that correlate with improved cognitive performance. However, current studies have not examined the association between PA performed in different habitual con...
    Oct 20, 2019
  • Abstract
    Brain decoding of affective meaning through personal stories
    Sensory and affective responses can be shaped by multiple ingredients such as sensory and conceptual information, social and affective values, past memories, relevance to the ‘self’, etc. All these ingredients construct affective meaning, which could dr...
    Oct 20, 2019
  • No Detectable Effect on Visual Responses Using Functional MRI in a Rodent Model of α-Synuclein Expression | eNeuro
    Parkinson’s disease (PD) is a progressive neurodegenerative disease that is typically diagnosed late in its progression. There is a need for biomarkers suitable for monitoring the disease progression at earlier stages to guide the development of novel neuroprotective therapies. One potential biomarker, α-synuclein, has been found in both the familial cases of PD, as well as the sporadic cases and is considered a key feature of PD. α-synuclein is naturally present in the retina, and it has been suggested that early symptoms of the visual system may be used as a biomarker for PD. Here, we use a viral vector to induce a unilateral expression of human wild-type α-synuclein in rats as a mechanistic model of protein aggregation in PD. We employed functional magnetic resonance imaging (fMRI) to investigate whether adeno-associated virus (AAV) mediated expression of human wild-type α-synuclein alter functional activity in the visual system. A total of 16 rats were injected with either AAV-α-synuclein ( n  = 7) or ...
    May 1, 2021 Freja Gam Østergaard
  • Abstract
    Presence of collateral circulation after local cerebral ischemia in rat does not affect the accumulation of brain tissue sodium, [Na+], measured by sodium magnetic resonance imaging.
    Brain [Na+] has been proposed to assess insult duration in evolving stroke (Wang et al, 2000 Stroke 31,1386). Stroke localization and the type of local blood supply may modify this relation. We hypothesized that the time course of [Na+] in cortical stroke (COR) where collateral circulation is present is different than in caudoputamen stroke (CP) where collateral circulation is absent. In Sprague-Dawley rats (~340 g) under isoflurane anesthesia focal ischemia was induced either by occlusion of the distal middle cerebral artery and both common carotid arteries or by insertion of an intraluminal suture through the internal carotid artery. 3D [Na+] data were obtained on a 3 T whole body scanner (GE MS) using a dual-tuned (23Na/1H), dual-quadrature birdcage RF coil. The infarct was located using ADC 1H images. [Na+] maps (twisted projection) were acquired every 5.3 min from which the [Na+] in % change from the average in normal cortex was measured vs. time after occlusion, Ta, in hours. The rate of [Na+] increa...
    Nov 9, 2003
  • Abstract
    Can oxidative stress explain the acute changes on MRI that are directly linked to eventual motor phenotype of cerebral palsy
    In our hypoxia-ischemia induced cerebral palsy animal model, acute changes in apparent diffusion coefficient (ADC) in fetal brain during uterine ischemia predicts which fetuses will become hypertonic. There is a ‘normal’ ADC threshold and only fetuses w...
    Nov 7, 2007
  • Abstract
    Rearrangement of adult cortical sensory maps after spinal cord injury: Functional MRI responses in cortex linked to Nogo receptor signaling
    Experience-driven changes of sensory inputs cause reorganization of cortical sensory maps in the adult brain. Our lab postulated that down-regulation of Nogo receptor (NgR) is one prerequisite for structural reorganization of synaptic circuitry. However...
    Nov 7, 2007
  • Abstract
    Respiratory brain area recruitment to passive foot motion in adolescents
    Locomotion or passive foot motion increases respiratory rate and tidal volume, a relationship of interest as a means to stimulate breathing for patients with sleep-disordered breathing, especially children with hypoventilation disorders. To determine th...
    Nov 4, 2007
  • Abstract
    Sensory fMRI analysis of neural substrates during brush texture perception vs. discrimination in humans
    Background and purpose- In humans, it has been demonstrated that neural substrates for tactile shape discrimination display a right-sided asymmetry. Right handed tactile object recognition has also been shown to result in predominantly right-sided neura...
    Nov 3, 2007
  • Abstract
    Evaluation of unpleasant emotions during cursor control from fMRI brain activity signals
    Recently, decoding emotions from brain activity signals has been drawn attentions to develop better communication tools based on computer devices. However, most existing studies focus on emotions elicited by passively viewing of emotional images or reco...
    Nov 14, 2017
  • Abstract
    Neural correlates of an associative memory of elapsed time
    The extent to which time duration is represented in associate memory remains under-investigated. We designed a time paired associate task (TPAT) in which participants implicitly learnt cue-time-target associations between cue-target pairs and specific c...
    Nov 13, 2017
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