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1451 - 1460 of 33803 results
  • Abstract
    Towards the development of a marmoset model of Parkinson's disease based on the spreading of human alpha-synuclein pre-formed fibrils
    The protein alpha-synuclein is widely disseminated within the brain of patients with advanced Parkinson’s disease (PD) and there is increasing evidence suggesting that this abnormal dissemination and accumulation of alpha-synuclein may be neuro-toxic. T...
    Oct 21, 2019
  • Abstract
    Mouse FMRI reveals mu opioid receptor-mediated effects of buprenorphine on whole brain functional connectivity
    Misuse of mu opioid receptor (MOR) drugs may cause addiction and is a leading cause to the rising opioid epidemic in North America. However, among clinically approved opioids a safer option to treat pain may be buprenorphine, which stands apart due to i...
    Oct 20, 2019
  • Abstract
    Brain activity associated with preferences for artworks depending on the context of human or AI creators
    Previously, it has been shown that aesthetic judgments of an artwork depend on contexts, such as the authenticity (Newman et al., 2011), or the display place (Kirk et al., 2009). In the present study, we aimed to examine whether the contextual informati...
    Oct 19, 2019
  • Abstract
    Modeling multimodal brain-predicted age in early symptomatic and preclinical Alzheimer disease
    Background: The “brain-predicted age” approach quantifies apparent brain age compared to normative trajectories of neuroimaging features. Elevated brain-predicted age has been observed in symptomatic Alzheimer disease (AD), but has not been evaluated in...
    Nov 11, 2021
  • Abstract
    Associations between neural correlates of imagined walking and community mobility: preliminary results from the Mind in Motion study
    Studies have shown associations between functional brain activity and lab-based gait measurements, where increased brain activity is associated with better gait performance. Traditionally, gait performance in laboratory settings has been quantified via ...
    Nov 10, 2021
  • Abstract
    Predictability and controllability alter neural reactivity to threat
    Emotional resilience to stressful events depends, in part, on our ability to predict and control threats in the environment. Thus, determining the neural response to predictable and controllable threats, may provide new insights into brain processes tha...
    Nov 9, 2021
  • Abstract
    De-differentiation of functional networks in corticobasal syndrome
    There is an increasing acceptance that neurodegenerative diseases manifest as network disorders. In particular, we have established that corticobasal syndrome (CBS) is characterized by structural network degeneration involving grey matter and white matt...
    Nov 9, 2021
  • Abstract
    Il-12 contributes to secondary damage and functional impairment after spinal cord injury.
    Traumatic spinal cord injury (SCI) is a relatively frequent event that imposes a massive burden on the health, quality of life and socioeconomic situation of affected persons. Tissue damage after SCI occurs in two phases: primary and secondary damage. P...
    Nov 9, 2021
  • Abstract
    Directed effective connectivity in the human and monkey brain: Auditory cortex impact on inferior frontal gyrus, hippocampus and anterior cingulate cortex
    The correspondences or differences between human and nonhuman primates in connectivity between auditory cortex and other brain regions remain open questions: What is the evidence for evolutionary conservation or specialization in effective connectivity ...
    Nov 6, 2018
  • Effects of Early Life Stress on [11C]DASB Positron Emission Tomography Imaging of Serotonin Transporters in Adolescent Peer- and Mother-Reared Rhesus Monkeys | Journal of Neuroscience
    Peer-reared (PR) rhesus monkeys with early maternal separation later exhibit aggressiveness, impaired impulse control, alcohol abuse, and low CSF 5-hydroxyindoleacetic acid. This study compared regional brain serotonin transporter (SERT) binding between nine PR and seven mother-reared rhesus monkeys with [11C]DASB positron emission tomography (PET) imaging. Parametric images of binding potential (BP) (which is proportional to B max/ K D, in which B max is transporter density and K D is dissociation constant) and relative blood flow ( R 1) were generated by the two-parameter multilinear reference tissue model. R 1 images were used for coregistration and normalization of PET parametric data to the magnetic resonance imaging template space. Group BP differences were analyzed voxelwise by Student's t test in SPM2. Region of interest-based parameter values were also calculated to obtain the magnitude of regional BP differences between the two groups. For the PR group, SERT BP was decreased by 10–23% across a ra...
    Apr 26, 2006 Masanori Ichise
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