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of 33799 results
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AbstractAge-related cognitive decline varies between individuals and is believed to be influenced by various factors, including lifestyle (e.g. intellectual engagement, fitness, and caloric restriction). A rat model of ‘healthy ageing’ was implemented by combin...Oct 20, 2019
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AbstractAn ultimate goal of medical imaging is the development of a non-invasive technique capable of providing images equivalent to histo-pathological microscopic observation. Such a technique would have profound clinical impact, especially for those diseases ...Nov 4, 2007
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AbstractThe PAX6 gene encodes a highly conserved transcription factor required for various aspects of anatomical and functional development of the eye and brain. Heterozygous loss-of-function mutations in PAX6 cause aniridia in humans and the Small eye trait in...Nov 12, 2016
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AbstractGabapentin (Neurontin) is widely used for the treatment of neuropathic pain. In this study, we used functional MRI of conscious rats to localize changes in neural activity within the brain resulting from gabapentin infusion. Two groups of rats received ...Nov 7, 2007
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AbstractAlzheimer’s disease (AD) causes tremendous damage to the brain over the course of the life of those afflicted. A major focus of AD research pertains to the development of diagnostic tools and methods to examine subtle pathological changes that occur ear...Oct 22, 2019
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AbstractInflammatory response after ischemic brain injury is mediated by Toll-like receptors (TLR) located on the microglia. Tlr2-deficient mice represent a model of the modified neuroinflammation, which is hypothesized to result in the modified post-stroke rec...Nov 9, 2021
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AbstractIn the mammalian brain, the insula is the primary cortical substrate involved in the perception of taste. Recent imaging studies in rodents have identified a ‘gustotopic’ organization in the insula, whereby distinct insula regions are selectively respon...Oct 22, 2019
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AbstractSpreading Depolarization (SD) is a neurophysiological phenomenon of large-scale depolarization of brain cells followed by a period of long-lasting neuronal inactivity. SD propagates through the brain at approximately 3-5 mm per minute causing an underly...Nov 13, 2017
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AbstractA large body of evidence suggests that progressive cell loss in midbrain and brainstem neuromodulatory structures is significantly implicated in age-related decline in memory function, and they are among the first structures affected in dementia. Howeve...Oct 23, 2019
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AbstractExposure to traumatic events can have adverse effects on cognitive and affective functions. However, traumatized individuals vary in their individual susceptibility to posttraumatic stress disorder (PTSD) development. Although prior research has suggest...Oct 23, 2019
