Restoration of functional connectivity is a major contributor to functional recovery after stroke. We investigated the role of reactive astrocytes in functional connectivity and recovery after photothrombotic stroke in mice with attenuated reactive glio...

Background: American-style football players are likely to have experienced exposure to repetitive head impacts. Several studies suggested an association between traumatic brain injury (TBI) and risk of developing misfolded p-Tau protein identified in ch...

Enlarged perivascular spaces (EPVS) have been recently proposed as a means to investigate abnormalities of the brain glymphatic system, which is considered to have a role in the clearance of neurotoxic metabolites. Multiple Sclerosis (MS) patients showe...

Although behavioral studies suggest that pain distress may alter the perception of somatic stimulation, neural correlates underlying such alteration remain to be clarified. The present study was aimed to test the hypothesis that expectation of pain might amplify brain responses to somatosensory stimulation in the anterior cingulate cortex (ACC) and the region including parietal operculum and posterior insula (PO/PI), both of which may play roles in regulating pain-dependent behavior. We compared brain responses with and subjective evaluation of physically identical nonpainful warm stimuli between two psychologically different contexts: one linked with pain expectation by presenting the nonpainful stimuli randomly intermixed with painful stimuli and the other without. By applying the event-related functional magnetic resonance imaging technique, brain responses to the stimuli were assessed with respect to signal changes and activated volume, setting regions of interest on activated clusters in ACC and bilat...

Clinician’s guidelines for selecting a suitable MS therapy rely on reproducible MRI measures such as T2 lesion load. Unfortunately, clinicians cannot determine the changes in myelin and inflammatory status of MRI visible lesions. Hence, emerging multimo...

Discoveries in the study of vascular dementia could lead to earlier diagnoses and new treatments for patients with Alzheimer’s disease.

Two motivated behaviors that are crucial for the expression of sexual behavior are sexual incentive motivation (SIM) and partner preference (PP). In the SIM test no physical contact is possible while In the PP test the subjects can interact with the sti...

Sports-related concussions, or mild traumatic brain injuries (mTBI), are extremely common and a major concern for athletes, athletic trainers, and coaches. Though quick concussion assessments can be conducted on the field to determine ability to return ...

A historically predominant view of the organization of the human brain has been a modular view where individual, isolated brain regions receive information, carry out a specific process, and pass that information on to other brain regions. The advent of functional magnetic resonance imaging (fMRI)

Using high-field MR technology (7 Tesla), detailed visualization of individual brain structures can now be achieved. Yet regardless of the field strength, the detail obtained is generally well above the cellular level, necessitating the fine-grained ana...