The world health organization estimates that there are currently 350 million people suffering from major depressive disorder. This is characterized by dysphoric mood and among the most serious consequences suiciding can became an option, apart from the ...

Alzheimer's disease (AD) has traditionally been associated with amyloid-β plaques, but growing evidence underscores the role of neuroinflammation in disease progression. The autoinflammatory hypothesis of AD suggests chronic immune dysfunction contributes to neuronal damage, making immune modulation a promising therapeutic strategy. Cannabidiol (CBD), a phytocannabinoid with anti-inflammatory properties, may offer therapeutic potential. This study investigates how CBD independently influences two key neuroinflammatory regulators in AD: the Indoleamine 2,3-dioxygenase (IDO) pathway and the cyclic GMP-AMP synthase (cGAS) pathway. Though mechanistically distinct, both shape CNS immune responses. Targeting these immune-metabolic axes provides a mechanistic alternative to amyloid- or tau-based approaches by addressing upstream drivers of neuroinflammation and immune dysregulation. Using the male 5XFAD transgenic AD mouse model, we administered CBD via inhalation and assessed IDO and cGAS expression using flow ...

Alzheimer's disease (AD) has traditionally been associated with amyloid-β plaques, but growing evidence underscores the role of neuroinflammation in disease progression. The autoinflammatory hypothesis of AD suggests chronic immune dysfunction contributes to neuronal damage, making immune modulation a promising therapeutic strategy. Cannabidiol (CBD), a phytocannabinoid with anti-inflammatory properties, may offer therapeutic potential. This study investigates how CBD independently influences two key neuroinflammatory regulators in AD: the indoleamine 2,3-dioxygenase (IDO) pathway and the cyclic GMP-AMP synthase (cGAS) pathway. Though mechanistically distinct, both shape CNS immune responses. Targeting these immune-metabolic axes provides a mechanistic alternative to amyloid- or tau-based approaches by addressing upstream drivers of neuroinflammation and immune dysregulation. Using the male 5XFAD transgenic AD mouse model, we administered CBD via inhalation and assessed IDO and cGAS expression using flow c...

The current study investigated sex differences in cannabidiol (CBD)-tetrahydrocannabinol (THC) interactions on antinociception and locomotor activity in rats. Experiment 1 tested the hypothesis that CBD enhances THC-induced antinociception on tests of a...

Title: Impact of cannabidiol (CBD) on anxiety symptoms in pediatric epilepsy patients: A preliminary analysisAuthors: Saurav Singh, Breanna Borg, Austin Morales, Julia Evanski, Jamie MacDougall, Amanda Weber, Aimee Luat, Hilary Marusak Funding: The Chil...

Cannabis is the most widely used illicit drug and its chronic use is associated with cannabis use disorder (CUD). THC is an agonist of CB1, and CB2 cannabinoid receptors that are found throughout the brain. The nucleus accumbens shell (NAcs) is importan...

Cannabis is one of the most popular illicit recreational drugs, after alcohol and tobacco. δ9-tetrahydrocannabinol (δ9-THC) is the main psychoactive ingredient in marijuana. It has two stereoisomers, δ9(+) THC and δ9(-) THC, of which the (-) enantiomer ...

Marijuana and its principal psychoactive component, THC, produce characteristic behavioral and physiological effects in humans. However, THC's sites of action in the human brain and their relationships to the drug's actions are not yet well understood. We have previously demonstrated using BOLD fMRI imaging that THC produced dose-related alterations in brain function in several brain regions including nucleus accumbens, amygdala, anterior cingulate, and cerebellum. The purpose of the this study was to determine the relative contributions of neuronal and non-neuronal factors to the observed BOLD signal changes. With that in mind, we examined the effects of THC on cerebral blood flow using arterial spin labeling. Chronic marijuana users were injected iv with THC (0, 0.5, 1, and 3 mg over one-minute in an ethanol vehicle) while undergoing fMRI scanning. A single 8 mm slice containing motor cortex was imaged during rest and motor cortex activation (finger tapping). We found the average flow in the slice at res...

The abuse potential of marijuana in humans is well established but scientific evidence for reinforcing properties of its psychoactive constituent delta-9-tetrahydrocannabinol (THC) in animals is lacking. In the present experiments, high rates of self-administration behavior were consistently maintained in squirrel monkeys by intravenous injections of THC. Mean rates of responding ranged from 0.1 to 0.4 response/sec during daily 1-hr sessions, using a fixed-ratio 10, time-out 60 sec, schedule of i.v. THC injection with doses of 2 to 4 mcg/kg/injection. A second-order, fixed-interval schedule with fixed-ratio components was also studied, in which THC was repeatedly injected only at the end of each daily session in association with a brief visual stimulus (each completion of a fixed-ratio unit during a 30-min fixed interval produced only the brief visual stimulus). Mean rates of responding ranged from 0.06 to 0.2 responses/sec when 10 consecutive injections of 2 to 4 mcg/kg/injection THC spaced 2-sec apart en...

Cannabidiol (CBD) is a non-psychoactive compound derived from the cannabis plant, Cannabis sativa. Previous research has shown CBD’s wide ranging therapeutic effects from antidepressant, antipsychotic, and anti-anxiety studies to preventing social-recog...