2022 Gruber Neuroscience Prize
May 17, 2022, New Haven, CT – The 2022 Gruber Neuroscience Prize is being awarded to Larry Abbott, PhD, of Columbia University, Emery Neal Brown, MD, PhD, of the Massachusetts Institute of Technology and Massachusetts General Hospital, Terrence Sejnowski, PhD, of the Salk Institute for Biological Studies and UC San Diego, and Haim Sompolinsky, PhD, of the Hebrew University of Jerusalem and Harvard University, for their seminal contributions to the fields of computational and theoretical neuroscience. As datasets have grown ever larger and more complex, these fields have played an increasingly important role in helping scientists unravel the mysteries of the how the brain functions in both health and disease.
The Gruber Neuroscience Prize, which includes a $500,000 award, will be presented to Abbott, Brown, Sejnowski, and Sompolinsky, in San Diego, California, Nov. 13 at the annual meeting of the Society for Neuroscience.
“These four remarkable scientists have applied their expertise in mathematical and statistical analysis, physics, and machine learning to create theories, mathematical models, and tools that have greatly advanced how we study and understand the brain,” says Joshua Sanes, Professor of Molecular and Cellular Biology and Founding Director of the Center for Brain Science, Harvard University, and member of the Selection Advisory Board to the Prize. “Their insights and research have not only transformed howexperimental neuroscientists do their research, but also are leading to promising new ways of providing clinical care.”
In landmark studies, Abbott suggested how spike-timing dependent plasticity (STDP), a process by which neurons adjust their synaptic connections with each other, supports memory and learning. In collaboration with experimental groups, he has uncovered functional principles underlying neural circuits involved in sensory processing, including olfaction and electrosensation, and motor behaviors ranging from rhythmic pattern generation to navigation.
Brown’s groundbreaking findings include a novel algorithm that decodes the position of an animal by observing the activity of a small group of place cells in the animal’s brain. This finding established a new framework for specifying the relationship between the spike trains (the timing sequence of firing neurons) and factors from the outside world. Brown went on to develop more accurate and informative ways to monitor the brain state of patients receiving anesthesia for surgery.
Among Sejnowski’s transformative contributions to computational neuroscience is the introduction of the first unsupervised learning algorithm for independent component analysis (ICA), which is now a mainstay in brain imaging. He has also shown that sleep spindles (brain wave patterns during non-rapid eye movement, or NREM, sleep) are not synchronous across the cortex, as was previously believed, but instead create circular traveling waves—a finding that has shed significant new light on how the brain learns and how memory is affected in disorders such as Alzheimer’s disease.
Sompolinsky’s pioneering research provided a deep understanding of attractor-network models that describe the collective behavior and informational processing of large, complex neural circuits in the brain. He has also described how the combination of neuronal excitation and inhibition lead to chaotic yet controllable patterns of activity in the brain—findings that have profoundly influenced our understanding of brain systems.
“By demonstrating that physics and mathematics can make an enormous contribution to neuroscience, Drs. Abbott, Brown, Sejnowski, and Sompolinsky have inspired an entire new generation of physicists and other quantitative scientists to follow in their footsteps,” says Frances Jensen, Professor and Chair Department of Neurology, Co-Director Penn Medicine Translational Neuroscience Center, Perelman School of Medicine, University of Pennsylvania, and chair of the Selection Advisory Board to the Prize. “The ramifications for neuroscience have been broad and profound. It is a great pleasure to be honoring each of them with this prestigious award.”
The Society for Neuroscience partners with the Foundation on the Prize and nominates the members of the Selection Advisory Board that chooses the Prize recipients. Its members are: Frances Jensen, University of Pennsylvania (Chair); Pierre Magistretti, King Abdullah University of Science and Technology; Eric Nestler, Icahn School of Medicine at Mount Sinai; Anthony Phillips, University of British Columbia; Angela Roberts, University of Cambridge; Joshua Sanes, Harvard University; and Carla Shatz, Stanford University.
The Gruber International Prize Program honors individuals in the fields of Cosmology, Genetics and Neuroscience, whose groundbreaking work provides new models that inspire and enable fundamental shifts in knowledge and culture. The Selection Advisory Boards choose individuals whose contributions in their respective fields advance our knowledge and potentially have a profound impact on our lives.
The Gruber Foundation was established in 1993 by the late Peter Gruber and his wife Patricia Gruber. The Foundation began its International Prize Program in 2000, with the inaugural Cosmology Prize.